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Complementary Insights from Environmental DNA and Environmental RNA Metabarcoding for Marine Biodiversity Assessment Around San Andres Island, Colombia

This paper compares eDNA and eRNA metabarcoding in marine environments, finding eRNA better captures active communities and reveals habitat-specific differences.

Partitioning Fraction of Variance Explained into Strong Localized Effects and Weak Diffuse Effects

The paper introduces a decomposed FVE estimation framework to improve heritability estimates by accounting for heavy-tailed SNP effects and violations of the bounded-kurtosis condition.

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

This study uses Cas12a-based knockout screens to identify genetic interactions in the DNA damage response, revealing synthetic lethal and buffering interactions with therapeutic implications.

Comparative genomics reveals extensive genomic conservation and limited microdiversification among Xenorhabdus bovienii isolates recovered from a single Steinernema feltiae isolation event.

The paper compares genomic data of four closely related Xenorhabdus bovienii isolates to assess their genomic conservation and microdiversification.

Redox stress agents strongly enhance mutagenesis during horizontal gene transfer in bacteria and leave distinct mutational and metabolic footprints

The paper shows redox stress agents increase mutagenesis during bacterial conjugation and leave distinct mutational and metabolic signatures.

Cross Potential Selection for Multiple Traits Considering the Progeny Distribution of Future Inbred Lines in Plant Breeding Programs

This paper introduces CPS-MT, a breeding strategy that improves a target trait while maintaining essential traits within ranges by evaluating cross-pairs based on predicted progeny distributions.

Gap junctions in the alimentary tract regulate reproductive span in C. elegans

This study shows that mutating inx-20, a gap junction gene in C. elegans, extends reproductive span without significantly affecting lifespan.

The WormFood CURE: Screening for bioactive metabolites that antagonize the Caenorhabditis elegans Ras signaling pathway

The paper presents a CURE model that identifies bacterial isolates producing bioactive metabolites antagonizing the C. elegans Ras signaling pathway through phenotype suppression.

Uncovering moonlighting role of mitochondrial presequence translocase machinery in SOD1-mediated ALS pathogenesis

This study identifies a novel interaction between mutant SOD1 and the TIM23 complex in yeast, revealing its role in mitochondrial dysfunction and ALS pathogenesis.

Characterization of a novel neurodevelopmental rare disease caused by a mutation within the autophagy gene ATG9B

The paper reports a novel neurodevelopmental disorder caused by a frameshift mutation in ATG9B, and characterizes its effects using cell models and knock-in mice.

Long-read RNA-seq resolves isoform-level and context-specific regulatory architecture of complex traits in cattle

The paper uses long-read RNA-seq to uncover isoform-level and context-specific regulatory effects in cattle, improving the resolution of molecular atlases and GWAS loci.

The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness

This study shows that the eutherian-specific histone H3.4 variant promotes male germ cell development and reproductive fitness through specific sequence variations.

A universal regulatory mechanism for prevention of replication restart from RNA:DNA hybrids

The paper identifies a conserved mechanism preventing replication restart from RNA:DNA hybrids in bacteria and mammals.

Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes

The paper identifies beta-tubulin variants associated with benzimidazole resistance in three Caenorhabditis species and shows species-specific patterns of resistance.

Evidence for G6PD variant classification from multiplexed functional assays

The paper classifies G6PD variants using functional assays to identify clinically relevant variants and those unlikely to contribute to G6PD deficiency.

Cytosine base editing workflow for quality-controlled multiplex-knockout hiPSC lines

The paper develops a cytosine base editing workflow to generate quality-controlled multiplex-knockout hiPSC lines for studying disease mechanisms.

Integrated Transcriptomic and Functional Analysis Reveals Tissue-Specific Molecular Pathology in Adolescent Idiopathic Scoliosis

The paper identifies tissue-specific molecular changes in paraspinal muscle and spinal cartilage in AIS patients, linking non-coding genetic risk variants to dysregulated developmental pathways.

Exploring the genetic architecture underlying dietary fiber content in Colombian Andean blueberry (Vaccinium meridionale Swartz)

The paper uses GWAS to identify genetic loci associated with dietary fiber traits in Colombian Andean blueberry, revealing polygenic control and candidate genes involved in fiber biosynthesis and remodeling.

A simple method of estimating rabies outbreak sizes from phylogenies

This paper introduces a method to estimate rabies outbreak sizes using phylogenies and validates it with simulated data and a real outbreak in the Philippines.

PEC: a robust algorithm to reconcile pedigree and SNP-chip data on the basis of LD block, haplotype information, and Mendelian conflicts

PEC corrects pedigree errors in livestock by using LD blocks, haplotype information, and Mendelian conflict checks, improving genomic evaluation accuracy.