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Are genetically defined "metapopulations" self-evident in YHRD?

The paper investigates whether YHRD's metapopulations are self-evident by analyzing genetic structure using cluster analysis and finds weak genetic structure that does not support clear subgrouping.

A Screen To Identify Protein Phosphatases with Roles in Circadian Period, Temperature Compensation and Output in the Neurospora Circadian Clock

The paper identifies protein phosphatases involved in circadian period, temperature compensation, and output in Neurospora by analyzing 39 non-essential phosphatases.

A comparative approach for selecting orthologous candidate genes in genome-wide associationstudies across multiple species

The paper develops a method to identify conserved causative genes across species using multi-species GWAS data, finding that conserved genes are more frequently associated with trait variation than expected by chance.

Investigating the role of phosphodiesterase Pde2 in coordinating the yeast Environmental Stress Response

This study investigates how Pde2 regulates the yeast Environmental Stress Response by affecting Msn2/4 activation and target gene expression, with minimal impact on Dot6 repression.

A key role for chromosome compartment interactions in directing Xist RNA localisation

This study shows Xist RNA localizes to A1-sub-compartments on the X chromosome, which are positioned peripherally in compacted chromosome territories.

Increased Osteoclast Activity Contributes to Bone Resorption and Osteopenia in a Rett Syndrome Mouse Model

This study identifies increased osteoclast activity as a key contributor to bone resorption and osteopenia in a Rett syndrome mouse model, showing an age-dependent shift in bone remodeling.

Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis

This study shows that loss of Cryptochrome 1 and 2 leads to COPD-like lung disease through disrupted epithelial proliferation and immune homeostasis, and that Nobiletin can alleviate these effects.

A pilot study for whole proteome tagging in C. elegans

This paper demonstrates a pilot study using fluorescent tags to label 30 C. elegans genes with three fluorophores, revealing new insights into protein expression and localization.

Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers

This study compares genomic and immunologic features of germline TP53-driven breast cancers to sporadic breast cancers, finding distinct patterns of genomic instability and immune infiltration.

Census and genetic analysis of the United States marmoset population

The paper analyzes the genetic diversity and population structure of US marmosets, revealing pre-colony population structure and generating a pedigree-based recombination map.

Two Novel Genes, Stb23 and Stb24, Conferring Multi-stage Resistance to Zymoseptoria tritici: Rapid Deployment in Marker-Assisted Wheat Breeding

This study identifies two new resistance loci, Stb23 and Stb24, against Zymoseptoria tritici and develops KASP markers for their use in wheat breeding.

Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans

This study identifies MUL-1 proteins as redox-responsive modulators of oxidative stress signaling in C. elegans, showing their role in buffering oxidative stress and preventing germ cell apoptosis.

kinference: Pairwise kinship detection for Close-Kin Mark-Recapture

The paper introduces the kinference R package for detecting close-kin pairs in genetic data to support demographic analysis in wildlife management.

The phenotypic nonspecificity of cell-to-cell signalling in Drosophila melanogaster.

The paper tests the hypothesis of redundant cell-to-cell signalling pathways by screening ligands to rescue a DPP hypomorphic wing growth phenotype, identifying partial rescues by HH, SEMA1A, and WNT2.

A screen for stress-induced sleep genes in C. elegans reveals a role for glutamate signaling

The paper identifies genes involved in stress-induced sleep in C. elegans, highlighting the role of glutamate signaling in sleep regulation.

Meiotic recombination spans almost entire chromosome arms in a fully monoarmed karyotype of an African annual killifish Nothobranchius virgatus

The paper analyzes meiotic recombination patterns in Nothobranchius virgatus, finding recombination spans nearly entire chromosome arms, excluding centromeres and telomeres.

Homozygous c.820G>A variant in MGME1 contributes to multi-systemic mitochondrial dysfunction in an Indian patient cohort

This study identifies a homozygous MGME1 variant in an Indian cohort causing mitochondrial dysfunction through impaired mtDNA replication and repair.

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types

This study compares genome instability in articular chondrocytes and skin fibroblasts using whole-genome sequencing, revealing distinct mutation patterns and mutagenic mechanisms between the two cell types.

A General Statistical Framework for Hardy-Weinberg Equilibrium Inference on the X Chromosome

The paper develops a statistical framework for Hardy-Weinberg equilibrium testing on the X chromosome, showing that existing methods can have inflated type I error or misleading results when sex differences in minor allele frequency are present.

Multisite Evaluation of an Amplification-based Nanopore Sequencing Solution to Analyze Challenging Clinically Relevant Variants in Genes Associated with Hereditary Diseases

This study evaluates a nanopore sequencing workflow for detecting complex variants in hereditary disease genes across multiple labs, finding high agreement with standard methods.