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AVPR2 antagonism with tolvaptan alters medullary cell responses and attenuates kidney injury

This study shows that Tolvaptan reduces medullary cell stress and inflammation in kidney injury models.

Epidemic Risks associated with high-temperature replicating infectious hematopoietic necrosis virus (IHNV) field isolates: from molecular characterization to host pathogen interactions

This study examines how rising water temperatures affect IHNV replication and host-pathogen interactions, identifying thermotolerant isolates and validating zebrafish larvae as a model for virulence assessment.

Spectroscopy-Based Machine Learning to Predict Stem-End Rot in Avocados with the Temporal Effects

This paper predicts stem-end rot in avocados using hyperspectral data and machine learning models, finding that physics-informed neural networks outperform traditional approaches by incorporating temporal dynamics.

Arthroscopic Raman Probe Provides Biomarkers of TMJ Tissue Composition that Account for Tissue Function

This study validates arthroscopic Raman spectroscopy for quantifying TMJ tissue composition and mechanical properties, showing strong correlations with indentation and tensile modulus.

Resolution of the circulating pathogenic phenotype of alpha-1 antitrypsin deficiency following liver transplantation

This study evaluates changes in circulating alpha-1 antitrypsin (AAT) monomers and polymers after liver transplantation in PiZZ AAT deficiency patients.

T cell-derived IFNγ instructs ECM crosslinking by cardiac fibroblasts through LOXL3 in experimental cardiometabolic HFpEF

This study identifies T cell-derived IFNγ as a driver of ECM stiffening in HFpEF via LOXL3 in cardiac fibroblasts, showing therapeutic potential for targeting this pathway.

Management of Root-Knot Nematode-Fusarium Wilt Complex with different Bio-management methods in Tomato (Solanum lycopersicum L.) var Srijana

This study evaluates biocontrol agents and grafting with resistant rootstocks to manage the root-knot nematode-Fusarium wilt complex in tomato under polyhouse conditions, finding grafting onto S. torvum and S. melongena most effective.

Geographic distribution of Adult Salmon Enteritis (ASE), Enterocytozoon schreckii, and Ceratonova shasta in Chinook Salmon Oncorhynchus tshawytscha (Walbaum, 1792) in Oregon and Washington state and expanded histopathologic description of ASE

The paper examines the geographic distribution of Adult Salmon Enteritis (ASE) and its association with parasites in Chinook Salmon, finding ASE is prevalent in Columbia Basin but absent in Puget Sound.

First Report of Soft Rot Caused by Pectobacterium brasiliense on Summer Squash in Mississippi, USA

The paper identifies Pectobacterium brasiliense as a new pathogen causing soft rot in summer squash in Mississippi using phenotypic and molecular methods.

Cardiac Hemorrhage Precedes Hypertension-induced Fibrosis inPlasminogen Activator Inhibitor-1 Deficient Mice

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

Sexually Dimorphic Transdifferentiation of Endothelial Cells in Atherosclerosis

This study identifies sex-specific endothelial cell transdifferentiation trajectories in atherosclerosis, revealing distinct fates in males and females and a novel direct EC-to-adipocyte transition.

Host response against SARS-CoV-2 infection is impacted by allosteric modulation of cholinergic and purinergic receptors

Ivermectin's protection in SARS-CoV-2-infected hamsters depended partly on both α7 nicotinic and P2X4 receptors; in co-cultures its effects were α7nAChR-independent, and P2X4 blockade prevented CXCL10 induction at 48 hpi.

Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

This study identifies mitochondrial dysfunction and impaired mitophagy as key drivers of cardiac damage in Fabry disease and shows that L-arginine supplementation can prevent cardiac abnormalities.

Histological morphometric correlates of MRI-defined cortical thinning in temporal lobe epilepsy

This study investigates the histological correlates of MRI-defined cortical thinning in temporal lobe epilepsy, finding that thinning is associated with altered neuronal packing and cell-size distributions rather than neuronal loss.

Multi-scale histology reveals localized ageing signatures in normal human colon

This paper uses multi-scale histology to identify localized age-related changes in normal human colon tissue using H&E images and machine learning.

Phylogenomic screening reveals idsA2 loss conferring nitroimidazole cross-resistance in Mycobacterium tuberculosis

A length- and mutation-load-corrected homoplasy screen of 1,813 MDR-TB genomes flags idsA2; its loss raises pretomanid MIC fourfold, delamanid and ethambutol twofold, via isoprenoid flux redirection.

Hidden Players: Latent Viruses Can Modulate Plant Disease Outcomes in Coinfection Contexts

This study shows latent viruses can alter disease severity and viral accumulation in plant coinfections, with outcomes depending on host and viral genotypes.

Temperature conditions allowing metamorphosis of Hyalomma marginatum nymphs: insights from laboratory experiments

This study investigates the temperature conditions required for the metamorphosis of Hyalomma marginatum nymphs through laboratory experiments, finding that development thresholds and degree-days are critical factors.

Deletion of LRP1 in Smooth Muscle Cells Induces Infrarenal Aortic Aneurysms in Mice

This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.

KRT7CreER Ferrets Enable Lineage Tracing of Ductal Epithelia and Pancreatic Remodeling

This study uses KRT7CreER ferrets to trace ductal epithelial lineage and pancreatic remodeling in health and cystic fibrosis.