Discover, rate, and verify biology preprints.

Two polymorphs of an independent amyloid core in medin's C-terminal region.

The paper identifies two polymorphs of an independent amyloid core in the C-terminal region of medin, showing it has multiple aggregation-prone regions.

Long-range chromatin interactions nominate candidate susceptibility genes at non-coding PDAC risk loci

The paper fine-maps GWAS risk variants for PDAC and identifies candidate target genes through chromatin conformation capture, finding functional interactions and eQTLs at specific loci.

RhoA effectors ROCK and SLK/LOK oppositely regulate VE-cadherin mobility at endothelial junctions

This study shows that ROCK and SLK/LOK oppositely regulate VE-cadherin mobility at endothelial junctions through distinct mechanisms.

Substrate recognition and ion coupling mechanism of the human VIAAT

The paper determines the structures of human VIAAT in multiple functional states and elucidates its substrate recognition and ion coupling mechanism.

Behavioral Markers of Essential Tremor Correlate with Distributed Alteration of Brain Functional Connectivity

The paper investigates how behavioral markers of essential tremor correlate with changes in brain functional connectivity using resting-state fMRI and kinematic data.

Connectivity predicts where computation forms and where it can be changed

The paper shows that neural connectivity defines classes that organize computation and predicts how interventions affect dynamical motifs.

Defining cell type-specific diurnal gene expression in the mouse retina

The paper identifies cell-type-specific diurnal gene expression patterns in the mouse retina using single-nucleus RNA sequencing.

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase

The paper identifies potent reaction hijacking inhibitors targeting Plasmodium falciparum asparagine tRNA synthetase, showing high selectivity and resistance refractoriness.

Multi-Lab Testing of Early Preclinical Discoveries Identifies Promising Treatments

The paper evaluates multi-laboratory studies to identify promising treatments by assessing effect sizes and experimental rigor across different medical fields.

Sex-based differences in fibrosis markers in human abdominal aortic aneurysms

The paper identifies sex-based differences in fibrosis markers in human abdominal aortic aneurysms, showing elevated FAP and collagen in females.

Elephant seal cells export iron and form lipid droplets to evade lipid peroxidation

This study identifies a unique mechanism in elephant seal cells that prevents lipid peroxidation through lipid droplet formation and iron export, rather than traditional antioxidant pathways.

kri-1/KRIT1 restrains skn-1/NRF2 activation to promote innate immune and lipid homeostasis

This study identifies kri-1/KRIT1 as a regulator that limits skn-1/NRF2 activity to control immune responses and lipid homeostasis in C. elegans, supporting reproductive health.

ProtoPure: Literature Mining and Analysis of Protein Purification Protocols at Proteome Scale

ProtoPure automates the extraction and analysis of protein purification protocols from literature, revealing trends in recombinant expression practices and diverse downstream purification strategies.

Movement refinement and cholinergic regulation of outcome-dependent updating during skilled reaching.

This study investigates how movement refinement and cholinergic signaling influence skilled reaching in mice, finding that ACh levels and outcome-dependent adjustments play roles in updating movement execution.

The Endothelial Cell-Expressed Prion Protein Prnd/Doppel Promotes Neovascularization and Long-term Recovery after Ischemic Stroke

This study shows that Prnd/Doppel in endothelial cells promotes vascular remodeling and long-term recovery after stroke, improving neuronal survival and reducing inflammation.

Room-temperature light-state structure of the AsLOV2-Rac1 optogenetic actuator by sheet-on-sheet serial femtosecond crystallography

The paper reports room-temperature light-state structures of AsLOV2-Rac1 using serial femtosecond crystallography, revealing structural changes upon light activation.

Live-cell, single-molecule imaging resolves the dual nature of mRNA silencing by SARS-CoV-2 Nsp1

This study uses live-cell imaging to show SARS-CoV-2 Nsp1 silences mRNAs by reducing their numbers through two cap-dependent mechanisms, while viral UTRs enhance translation but do not protect from Nsp1.

Complex I is essential for embryonic stem cell proliferation through NADH-mediated redox signaling

This study shows that Complex I is essential for ESC proliferation via NADH-mediated redox signaling, independent of energy or ROS levels.

MHC II-expressing bone marrow megakaryocytes are noncanonical antigen presenting cells and activate CD4+ T cells ex vivo

The paper identifies MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4+ T cells and modulating immune responses.

Label-free volumetric dynamic atlas of fresh mouse organs using dynamic full-field optical coherence tomography

This study creates a label-free volumetric atlas of ten fresh mouse organs using D-FFOCT, revealing dynamic tissue features and heterogeneity across organs.