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Photoentrainment as Bayesian Inference: How the central circadian clock may weight and integrate the intensity and wavelength of natural light to estimate astronomical time

The paper proposes a Bayesian model explaining how the circadian clock integrates light intensity and wavelength to estimate astronomical time despite natural variability.

Follow-up availability and the robustness of immune transcriptomic recovery after myocardial infarction

The paper assesses the robustness of immune transcriptomic recovery after myocardial infarction by evaluating how missing data and assay availability affect inflammatory-response scores over time.

A Systems Theory of Cardiac-Autonomic Trajectories and Equilibria

This paper develops a theoretical framework to analyze cardiac-autonomic regulation using dynamical systems theory and demonstrates its properties through simulations.

A candidate HNRNPU-CHD2 RNA-processing axis in neurodevelopmental disease

The paper identifies a HNRNPU-CHD2 RNA-processing axis linked to neurodevelopmental disease by showing HNRNPU depletion causes splicing changes in CHD2 that may lead to nonsense-mediated decay.

Enzymatic attachment of antigens to probe immune modulation by skin commensals

This study uses recombinant sortase to attach antigens to Gram-positive bacteria, demonstrating a non-genetic method to induce protective immunity in vivo.

Shared and divergent features of the immune response to acute and chronic Trypanosoma cruzi infection in mice revealed by cardiac transcriptomics

This study uses cardiac transcriptomics in mice to compare immune responses during acute and chronic Trypanosoma cruzi infection, identifying shared and divergent features.

Distinct medial septal GABAergic pathways differentially regulate spatial memory and network activity

The paper identifies distinct septal GABAergic pathways regulated by PV+ and CB+ neurons, showing they differentially support spatial memory and network activity.

Socio-demographic gradients in traumatic brain injury disability, severity and nutrition: a two-level analysis of the Global Burden of Disease Study 2023 and NHANES 2011-2014

This paper examines socio-demographic gradients in traumatic brain injury (TBI) disability, severity, and nutrition using global and US-based data, finding persistent disparities and nutritional risks among food-insecure TBI survivors.

Endogenous PROM1 activation redistributes liver cancer cells along a preexisting differentiation axis

The paper shows PROM1 activation in liver cancer cells shifts their state along a preexisting differentiation axis, suggesting CD133's role extends beyond being a stem-like marker.

Cell-lineage selection interacts with development and life history to shape the rates and identity of heritable mutations

The paper shows that mutation transmission is influenced by developmental and life-history traits, altering mutation rates and identities across species.

Impact of acoustic property uncertainty on transcranial ultrasound simulation

This study quantifies how uncertainty in acoustic and thermal tissue properties affects transcranial ultrasound exposure estimates using simulations.

A Reproducible Pre-Transplant γδ T-cell Effector Signature Reveals Immune-Metabolic Programs Associated with Kidney Allograft Rejection

The paper identifies a pre-transplant γδ T-cell effector signature associated with kidney allograft rejection using multi-omics data from transplant recipients.

Systematic Spike Sorting Errors Revealed by Juxtacellular Ground Truth in the Awake Brain

The paper evaluates spike sorting errors in awake mice using ground-truth data and finds that false negatives increase significantly during bursting and spike overlaps, challenging conventional benchmarks.

Intraspecific trait variation shapes macro-scale patterns ofniche breadth and range size

The paper shows that greater intraspecific morphological variation in bulbuls predicts broader ecological niches and larger geographic ranges.

Exclusion from DNA double-strand breaks is a pervasive feature of the hnRNP family

The paper shows that most hnRNP proteins are excluded from DNA double-strand breaks, with hnRNPH1's exclusion dependent on its GYR domain and independent of recruitment pathways.

FoxO1 and HNF1α cooperatively remodel nucleosome architecture and mechanical stability to activate transcription

This study shows FoxO1 and HNF1α work together to change nucleosome structure and stability to activate transcription.

A Deep Phylogenetic Split Between Short- and Long-Wavelength-Tuned Visual Systems in Surgeonfishes (Acanthuridae)

This study investigates visual plasticity in surgeonfishes by analyzing opsin gene expression across 22 species, revealing a deep phylogenetic split in visual systems that predates ecological diversification.

Anti-TGFβ peptide P144 augments CAR-T cell efficacy through neutrophil recruitment and TME remodeling in malignant mesothelioma

This paper shows that delivering the anti-TGFβ peptide P144 via CAR-T cells enhances their efficacy in mesothelioma by recruiting neutrophils and remodeling the tumor microenvironment.

Amyloid/RNA Condensates with Germ Granule Characteristics Are Present in Rat Epididymal Spermatozoa and Exhibit Prion-Like Propagation Activity

The paper identifies germ granule-like amyloid/RNA condensates in rat epididymal spermatozoa that exhibit prion-like propagation activity, suggesting a non-Mendelian mechanism for transmitting environmental information to offspring.

Spatial transcriptomics of pediatric tuberculosis lymph nodes reveals a conserved hypoxia_SPP1 niche

This study uses spatial transcriptomics to identify a hypoxia-associated SPP1-enriched microenvironment in pediatric TB granulomas that may contribute to incomplete bacterial clearance.