B. Huang

This study shows that polyQ expansion in HTT does not change the structure of the HTT-HAP40 complex, as revealed by biophysical and cryo-EM analyses.

This study evaluates the neutralization of SARS-CoV-2 501Y.V2 variant by antisera from two Chinese vaccines, showing preserved neutralizing titres against the variant.

This study shows that pre-infection with low-virulent or avirulent TBEV strains protects mice from lethal TBEV-Hypr infection but allows virus entry into the CNS.

This study shows a ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces persistent antibodies and long-term memory in mice for at least 7 months.

This paper introduces TASEC, a method that enhances protein labeling and detection by using split enzyme complementation with orthogonal tags, demonstrating applications in cell enrichment and interaction studies.

This study compares the early host responses to SARS-CoV-2, SARS-CoV, and MERS-CoV infections using transcriptome analysis, revealing distinct patterns of cytokine and antiviral gene expression.

This study shows HP1 proteins form phase-separated DNA condensates that are mechanically stable but can be dissolved by HP1β, with differences in DNA compaction linked to their disordered regions.

This study shows that drought duration affects the recovery of rice root microbiomes, with prolonged drought reducing resilience and altering microbial community dynamics.

The paper improves split fluorescent protein systems for better complementation efficiency and signal amplification in mammalian cells.

This study shows that ER chaperones BiP and Grp94 regulate proIGF2 folding and oligomerization, with BiP suppressing and Grp94 enhancing oligomerization under different ATP/ADP conditions.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This study identifies positive selection in the SARS-CoV-2 spike gene, particularly the D614G mutation, which may enhance viral entry and adaptability during the pandemic.

This study identifies a unique glycogen synthesis pathway in Chlamydiales using trehalose instead of ADP-Glucose, highlighting its role in survival and infectivity.

This study identifies ABD957, a selective ABHD17 inhibitor, which disrupts N-Ras depalmitoylation and inhibits NRAS-mutant AML growth, suggesting potential as a targeted therapy.

The paper shows that Par-3 and dynein mediate polarized endosome movement during asymmetric division, leading to Notch signaling asymmetry in daughter cells.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study shows that LFA-1 signaling, but not VLA-4, drives cytoskeletal changes enabling T cells to migrate upstream against shear flow.

This study identifies bosutinib as a radiosensitizer for breast cancer by targeting eIF4G1, enhancing radiation efficacy and reducing drug dosage.

This study shows that Scutellaria baicalensis extract and its compound baicalein inhibit SARS-CoV-2 replication and 3CLpro activity in vitro.

This study identifies membraneless protein granules formed by RTK oncoproteins that activate RAS/MAPK signaling independently of lipid membranes in cancer.

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

The paper shows that nanotopography induces dynamic changes in tight junction proteins by forming cytosolic complexes that regulate paracellular permeability.

This study shows that Sema3a reduces radiation-induced ROS levels and mitigates adverse effects on BMSCs by improving osteogenic differentiation and reducing adipogenic differentiation and inflammation.

This study examines the overwintering behavior and cold hardiness of the purple stem borer in its newly colonized northern range, identifying its survival strategies and potential distribution limits.

This study shows that low shear stress activates Smad 2/3 signaling in endothelial cells, leading to inward artery remodeling.

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

The paper develops a method to align semi-flexible 3D structures from super-resolution microscopy images with high accuracy and efficiency, demonstrating it on STORM images of ciliary distal appendages.