Author
C. Guo
Primary ORCID profile (0009-0001-7421-586X · 7 papers)Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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2018-2024 · peak 13/yrCo-Author Collaboration Network
10 top collaborators · 18 mutual co-author links50 papers
Recent·Most cited
- Cell BiologybioRxivPreprint
Lentiviral vector optimization enhances the expression and cytotoxicity of chimeric antigen receptors
C. Guo, H. Chen, J. Yu…·W. Zhu
This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.
DOI 10.1101/2021.07.11.451925 - ImmunologybioRxivPreprint
Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells
C. Kee, C. Metz-Zumaran, P. Doldan…·S. Boulant
This study shows that type III interferons are more effective than type I interferons in reducing SARS-CoV-2 infection in human intestinal epithelial cells.
DOI 10.1101/2021.06.14.448464 - BioengineeringbioRxiv
An Off-the-Shelf Bioadhesive Patch for Sutureless Repair of Gastrointestinal Defects
J. Wu, H. Yuk, T. L. Sarrafian…·X. Zhao
An off-the-shelf bioadhesive patch is introduced for facile sutureless repair of gastrointestinal defects, addressing various limitations of conventional suture-based treatments.
- MicrobiologybioRxivPreprint
Identification of Nocardia species using Autof MS 1000 and Bruker MALDI-TOF MS systems: A comparison
This study compares the performance of Autof MS 1000 and Bruker MALDI-TOF MS systems in identifying Nocardia species using clinical isolates and sequence analysis as a reference.
DOI 10.1101/2021.01.11.426310 - Cell BiologybioRxiv
The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
C. Guo, S. J. Tsai, Y. Ai…·S. Gould
This study shows the D614G mutation in SARS-CoV-2 spike enhances lysosomal trafficking and accumulation, contributing to increased infectivity and transmission.
DOI 10.1126/sciadv.ade5085 - ImmunologybioRxivPreprint
The PRC2-dependent epigenetic reprograming of the bladder epithelium exacerbates urinary tract infections
C. Guo, M. ZHAO, X. Sui…·X. S. Li
This study shows that PRC2-dependent epigenetic reprogramming in bladder urothelium worsens UTIs by promoting inflammation and impaired differentiation, and that inhibiting Ezh2 can improve disease outcomes.
DOI 10.1101/2020.10.22.350942 - MicrobiologybioRxiv
Immunoreactive peptide maps of SARS-CoV-2 and other human coronaviruses
N. Mishra, X. Huang, S. Joshi…·W. I. Lipkin
The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.
DOI 10.1038/s42003-021-01743-9 - MicrobiologybioRxiv
Systematic analysis of REBASE identifies numerous Type I restriction-modification systems that contain duplicated, variable hsdS specificity genes that randomly switch methyltransferase specificity by recombination.
J. M. Atack, C. Guo, T. Litfin…·M. P. Jennings
The paper identifies 5.9% of Type I R-M systems with duplicated hsdS genes that enable phase-variation through recombination, found in pathogens like Enterococcus faecalis and Listeria monocytogenes.
DOI 10.1128/msystems.00497-20 - BiochemistrybioRxiv
Out-of-register parallel β-sheets and antiparallel β-sheets coexist in 150 kDa oligomers formed by Aβ(1-42)
Y. Gao, C. Guo, J. O. Watzlawik…·A. K. Paravastu
This paper uses solid-state NMR to show that 150 kDa Aβ(1-42) oligomers contain both parallel and antiparallel β-sheets with a unique inter-strand registry shift.
DOI 10.1016/j.jmb.2020.05.018 - Plant BiologybioRxiv
Global Dynamic Molecular Profiles of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing
Z. Liu, Y. Zhou, J. Guo…·X. Sun
The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.
DOI 10.1016/j.molp.2020.06.010 - MicrobiologybioRxiv
A metabolic pathway for bile acid dehydroxylation by the gut microbiome
M. Funabashi, T. Grove, V. Pascal…·M. A. Fischbach
This paper completes the metabolic pathway for bile acid dehydroxylation by the gut microbiome and demonstrates its heterologous expression in a non-producing commensal.
DOI 10.1038/s41586-020-2396-4 - BiochemistrybioRxivPreprint
Use of extracellular polymer substances as additives for improving biogas yield and digestion performance
This study shows that adding extracellular polymer substances (EPS) increases methane production in anaerobic digestion by enhancing microbial communities and electron transfer, without affecting sludge properties.
DOI 10.1101/699314 - Cancer BiologyCell ReportsPeer-reviewed
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
Y. Wang, J. Zhang, S. Ren…·H. Ji
This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.
DOI 10.1016/j.celrep.2019.06.026 - Cell BiologybioRxiv
The SUMO Protease SENP3 Regulates Mitochondrial Autophagy Mediated by Fis1
E. L. Waters, K. A. Wilkinson, R. E. Carmichael, C. Guo
This study identifies SENP3 as a regulator of stress-induced mitophagy through Fis1 deSUMOylation, showing that SENP3 stabilizes Fis1 localization and promotes mitochondrial autophagy.
DOI 10.15252/embr.201948754 - BiophysicsbioRxiv
Conformational Flexibility of p150Glued(1-191) Subunit of Dynactin Assembled with Microtubules
C. Guo, J. C. Williams, T. Polenova
This paper uses NMR spectroscopy to study the conformational flexibility of the p150Glued N-terminal region when bound to microtubules, revealing disordered regions and structural elements involved in microtubule binding.
DOI 10.1016/j.bpj.2019.07.036 - BioengineeringbioRxiv
Fast, volumetric live-cell imaging using high-resolution light-field microscopy
H. Li, C. Guo, D. Kim-Holzapfel…·S. Jia
This paper introduces high-resolution light-field microscopy for live-cell imaging with subcellular resolution and fast volumetric acquisition.
DOI 10.1364/boe.10.000029 - MicrobiologybioRxiv
Impact of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae
S. Zhou, Y. Huang, X. Mao…·Q. Qin
This study investigates the effect of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae, showing increased 1,3-PDO production and altered byproduct formation.
DOI 10.1371/journal.pone.0200978