D. Xu

The paper identifies meninges as a site for B cell development and CNS-antigen-specific negative selection in mice and NHPs.

This study identifies changes in the urinary proteome of rats undergoing regular swimming exercise, showing distinct protein differences linked to glucose metabolism and immunity.

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

This paper develops a method using gold nanoclusters to deliver siRNA into plant cells, achieving efficient gene knockdown with minimal toxicity.

This study shows that HMGB1 is sequestered by plasma sialoglycoproteins at physiological pH but is released during sepsis when pH and zinc levels drop, leading to immune activation.

The paper identifies two RNA fragments that can synthesize a 9-mer poly-lysine in Mg2+ solution, suggesting a mechanism for protein-free peptide ligase.

This study identifies a de novo germline mutation in Dusp10 that accelerates autoimmune diabetes in NOD mice by increasing susceptibility through CRISPR validation and PD-L1 expression analysis.

REGALS deconvolves X-ray scattering data from evolving mixtures by incorporating prior knowledge and regularization, enabling analysis of complex datasets with unknown components.

This study shows that CSNK1G2 inhibits RIP3-mediated necroptosis, reducing testis aging in mice and conserved in humans.

The paper shows red-light promotes mutualism between begomovirus and whitefly by stabilizing βC1, which inhibits plant defenses through interference with PIFs and MYC2 transcriptional activity.

This study shows that enhanced RNA-directed DNA methylation (RdDM) in reproductive organs increases DNA methylation, ensuring sexual reproduction in rice by regulating gene expression.

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This study identifies RSK-ABCB1 and HIF-1-FECH pathways regulated by MEK that reduce PpIX accumulation in cancer cells.

This study shows that KLF14 overexpression reduces infarct size and preserves cardiac function after myocardial infarction by protecting mitochondria and increasing PGC-1 levels.

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

The paper designs novel covalent inhibitors against SARS-CoV-2 using a deep Q-learning network and fragment-based drug design, generating 47 lead compounds available in a public repository.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study identifies ACE2-expressing cells in the digestive system using single-cell transcriptomes, suggesting the digestive tract as a potential route for 2019-nCov infection.

This study shows hesperetin reduces foam cell formation in macrophages by activating LXRα through AMPK-dependent mechanisms, enhancing cholesterol efflux and reducing cholesterol accumulation.

The paper identifies 840 genes involved in the DNA damage response through CRISPR/Cas9 screens and highlights specific gene functions in DNA repair and toxicity mechanisms.

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.

This paper introduces NMSR, a neural multi-scale self-supervised registration method for automated myocardial and cardiac blood flow dense tracking in echocardiograms, showing improved accuracy over existing methods.

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.