F. Guo

The Preclinical Inhibitor GS441524 in Combination with GC376 Efficaciously Inhibited the Proliferation of SARS-CoV-2 in the Mouse Respiratory Tract

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

Atomic structures of respiratory complex III2 , complex IV and supercomplex III2+IV from vascular plants

The paper presents atomic structures of mitochondrial complexes III2, IV, and their supercomplex III2+IV from vascular plants using cryoEM, revealing plant-specific features and challenging existing assumptions.

Controllable Fusion of Human Brain Organoids Using Acoustofluidics

This paper develops an acoustofluidic method to controllably fuse human brain organoids, enhancing standardization and reproducibility of fused models.

Panoramic Insights into the Microevolution and Macroevolution of Prevotella copri-containing Lineage in Primate Guts

This study investigates the micro- and macroevolution of Prevotella copri-containing lineage in primate guts, revealing co-evolution with humans, host jumping, and horizontal gene transfer.

An enormous Paris polyphylla genome sheds light on genome size evolution and polyphyllin biogenesis

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

Acoustofluidic Assembly of 3D Neurospheroids to Model Alzheimer's Disease

This paper introduces an acoustofluidic device to create 3D neurospheroids for modeling Alzheimer's disease neuroinflammation and amyloid-β toxicity.

One-stop Microfluidic Assembly of Human Brain Organoids to Model Prenatal Cannabis Exposure

This paper develops a microfluidic platform to assemble human brain organoids and models prenatal cannabis exposure effects on early brain development.

High Throughput Screening at the Membrane Interface Reveals New Inhibitors of Amyloid-β

This study identifies 5 small molecules that inhibit amyloid-β aggregation at the cell-membrane interface, which is relevant for Alzheimer's disease.

Frequency of mutations in 21 hereditary breast and ovarian cancer susceptibility genes among high-risk Chinese individuals

The paper assesses the frequency of deleterious mutations in 21 hereditary breast and ovarian cancer genes among 882 high-risk Chinese individuals, finding 19.5% carried such mutations, with higher rates in those with both breast and ovarian cancer histories.

Nonlinear Dispersive Cell Model for Microdosimetry of Nanosecond Pulsed Electric Fields

This study models the transmembrane potential distribution of cells under nanosecond pulsed electric fields by incorporating dielectric relaxation and electroporation effects.

Subcellular analyses of planarian meiosis implicates a novel, double-membraned vesiculation process in nuclear envelope breakdown

The paper identifies a novel double-membraned vesiculation process in planarian oocytes during nuclear envelope breakdown, revealing evolutionary adaptability of NEBD.