Franck Mortreux

Peculiar transcriptional reprogramming with functional impairment of dendritic cells upon exposure to transformed HTLV-1-infected cells

This study shows that HTLV-1-infected T cells alter the transcriptional and functional responses of dendritic cells, leading to a tolerogenic immune environment.

The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells

This study shows that MYCN and helicases DDX17/DDX5 have opposing roles in transcription termination and chimeric transcript production in neuroblastoma, with MYCN inhibiting helicase activity and promoting harmful RNA molecules.

Gene-to-Gene Coordinated Regulation of Transcription and Alternative splicing by 3D Chromatin Remodeling upon NF-κB activation

This study investigates how NF-κB activation through HTLV-1 Tax reorganizes 3D chromatin to coordinate transcription and alternative splicing of target genes.

SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors

SplicingLore provides a database of alternative exons regulated by 75 splicing factors, enabling analysis of splicing factor interactions and exon regulation.

The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

This study shows that Tax and HBZ, viral oncoproteins, alter mRNA splicing in T-cells by interacting with spliceosome components, leading to changes in cancer-related genes.

Intragenic recruitment of NF-κB drives alternative splicing modifications upon activation by the viral oncogene TAX of HTLV-1.

The paper shows that NF-κB recruitment to gene bodies via TAX activates alternative splicing through DDX17, affecting oncogenic pathways in HTLV-1 infection.

Interplay between coding and exonic splicing regulatory sequences

The paper shows that exons regulated by the same splicing factor share similar nucleotide composition and code for amino acids with similar physicochemical properties.

Interplay between gene nucleotide composition bias and splicing

The paper identifies GC-rich and AT-rich exons with distinct splicing factor dependencies and shows how nucleotide composition bias influences chromatin organization and exon recognition during splicing.