G. D'Angelo

Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity and pigment transfer

This study shows keratinocyte-derived extracellular vesicles regulate melanocyte dendrite formation, melanosome maturation, and pigment transfer, contributing to skin pigmentation and photoprotection.

Conformational dynamics of lipid transfer domains provide a general framework to decode their functional mechanism.

This study uses molecular simulations to show that lipid transfer domains (LTDs) from different LTP families share conserved dynamical features that correlate with their functional mechanism.

Anthrax intoxication reveals that ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains

This study identifies TMED2 and TMED10 as essential for anthrax toxin oligomerization by controlling lipid nanodomain formation at ER-Golgi contact sites.

Human Cytomegalovirus modifies placental small extracellular vesicle secretion and composition towards a proviral phenotype to enhance infection of fetal recipient cells

This study shows hCMV infection alters placental sEVs to promote viral spread to fetal cells.

Human cytomegalovirus infection changes the pattern of surface markers of small extracellular vesicles isolated from first trimester placental histocultures

This study examines how human cytomegalovirus infection alters surface markers on placental-derived small extracellular vesicles from first trimester histocultures.

Ultra-sensitive Protein-SIP to quantify activity and substrate uptake in microbiomes with stable isotopes

This paper introduces Protein-SIP, an ultra-sensitive method for quantifying isotope incorporation in microbiomes, showing higher sensitivity and accuracy than existing approaches.

Sugars dominate the seagrass rhizosphere

The paper shows seagrasses excrete high concentrations of sucrose into their rhizosphere, which accumulates due to microbial inhibition by phenolic compounds.

S-acylation controls SARS-Cov-2 membrane lipid organization and enhances infectivity

The paper shows that S-acylation by ZDHHC20 modifies SARS-CoV-2 membrane proteins, promoting lipid domain formation and enhancing viral infectivity.

Sphingolipid Control of Fibroblast Heterogeneity Revealed by Single-Cell Lipidomics

This study identifies sphingolipid composition as a driver of fibroblast heterogeneity and state transitions using single-cell lipidomics and transcriptomics.

Microvilli-derived Extracellular Vesicles Govern Morphogenesis in Drosophila wing epithelium

The paper identifies microvilli as the source of extracellular vesicles that transport Hedgehog morphogen in Drosophila wing discs, revealing the role of Prominin-like protein and cytoskeletal components in this process.

Centrosome amplification mediates small extracellular vesicles secretion via lysosome disruption

The paper shows centrosome amplification in pancreatic cancer cells increases small extracellular vesicle secretion through lysosomal dysfunction, promoting tumor invasion.

Regulated compartmentalization of enzymes in Golgi by GRASP55 controls cellular glycosphingolipid profile and function

This study identifies GRASP55 as a regulator of enzyme compartmentalization in the Golgi, which controls glycosphingolipid biosynthesis and cellular glycan profiles.

The Glyco-enzyme adaptor GOLPH3 Links Intra-Golgi Transport Dynamics to Glycosylation Patterns and Cell Proliferation

This study shows GOLPH3 regulates glycosylation and cell proliferation by controlling glyco-enzyme recycling and lysosomal degradation.

Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network

The paper identifies a homeostatic circuit that regulates sphingolipid levels at the trans Golgi network by linking sphingomyelin production to PtdIns(4)P dephosphorylation, which interrupts cholesterol and sphingolipid transport.