H. Huang

This study develops a computational strategy for in silico nanobody affinity maturation, achieving a 17.5-fold improvement in binding affinity for an anti-HIF-1α nanobody.

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

The paper uses protein-proofed single-cell RNA profiling to identify tissue cells vulnerable to SARS-CoV-2 infection across 36 tissues, revealing lung and cardiac cells as top targets.

This paper develops microbial strains for producing renewable fatty acid esters, achieving high yields and economic competitiveness in bioproduction.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

This paper develops a bio-active scaffold combining HMGB1 and kartogenin to enhance meniscus healing, showing activation of stem cells and promotion of tissue repair in vitro and in vivo.

This study identifies SIZ1-mediated SUMOylation of ROS1 as a mechanism enhancing ROS1 stability and promoting active DNA demethylation in Arabidopsis.

The paper examines the Quaternary legacy on biodiversity in the Mountains of Southwest China using comparative phylogeography, revealing the role of riverine barriers and glacial cycles in shaping genetic structure across vertebrate species.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

This paper demonstrates a method to enable random access of DNA-encoded files in large-scale archival storage by using silica capsules with barcode labels for efficient file selection.

This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

The paper assesses changes in drifting fish egg composition and abundance in the Xijiang River after dam construction, linking these changes to environmental factors.

This study develops an accelerated AMD model using Cxcr5/Nrf2 double knockout mice, showing early AMD-like features such as retinal degeneration and protein upregulation.

This study shows PRV infection accelerates KIF1A degradation in axons, disrupting viral transport and highlighting a novel mechanism of viral manipulation of host kinesin motors.

This paper validates a diffusion MRI biomarker, DDVD/area, for detecting liver fibrosis in hepatitis-B patients, showing it effectively differentiates fibrotic from non-fibrotic livers.

This study shows that phytochrome C (phyC) in Brachypodium distachyon acts as a molecular timer that communicates night length information to the circadian clock protein ELF3, regulating photoperiodic responses.

This paper shows that PCH1 is a structural component of phyB-photobodies and stabilizes phyB as Pfr, affecting light, temperature, and circadian signaling in Arabidopsis.

The paper identifies differentially expressed proteins in tumor-associated vascular endothelial cells of colorectal cancer and links some to angiogenesis and metastasis.

This study uses single-cell RNA sequencing to analyze cellular heterogeneity in mouse pancreatic ductal adenocarcinoma progression, identifying epithelial-to-mesenchymal transition, inflammatory macrophages, and fibroblast subtypes.

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.

The paper examines social contact preferences in BDNF knockout mice, finding reduced preference for familiar conspecifics in phase-2 but not phase-1, suggesting impaired social cue processing.

The paper examines local adaptation and maladaptation in Capsella bursa-pastoris during its global range expansion by analyzing genetic diversity, phenology, and SNP correlations with environmental factors across three continents.

This study identifies EZH2 as a p53 mRNA-binding protein that enhances translation of gain-of-function p53 mutants, promoting cancer growth and metastasis, and shows that inhibiting EZH2 causes synthetic lethality in these cells.

The paper studies the population structure and genetic diversity of Pseudomonas syringae from kiwifruit leaves during an outbreak, revealing ecological interactions between pathogenic and commensal strains.

This study identifies that most KCNQ1 mutations causing long QT syndrome destabilize the voltage sensor domain, leading to mistrafficking and proteasomal degradation.

The paper examines how diet and lifestyle affect the gut microbiome and health in red-shanked doucs, identifying microbial biomarkers of dysbiosis.

This study identifies posttranslational modifications of RioK1 that regulate its stability and oncogenic activity in colorectal and gastric cancers.

This study uses IVIM parameters to differentiate early-stage hepatitis-B fibrotic livers from healthy livers with high accuracy.

The paper functionally complements Arabidopsis ELF3 with orthologs from Brachypodium and Setaria, showing conserved molecular and physiological roles despite sequence divergence.