H. Huang

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper examines ethical issues in disease naming and proposes a method using deep learning to find suitable substitutes for outdated disease names.

This study uses integrative omics to detect subtle molecular changes in porcine kidneys after remote ischemic conditioning, finding reduced inflammation and potential fibrosis markers.

This study identifies recurrent chromosome fusions and gene losses in parrots, revealing the role of transposable elements and genetic drift in neo-sex chromosome evolution.

This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

This paper introduces a water-reward task assay to quantify mutualistic cooperative behavior in mice and provides detailed procedures for its implementation.

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

This study maps the cellular dynamics and intercellular interactions in a mouse liver transplant model using single-cell RNA sequencing and CyTOF, revealing recipient cell dominance and macrophage-driven metabolic remodeling.

This study shows that agonistic CD40 antibody therapy in glioma models causes T cell dysfunction and reduces response to checkpoint inhibitors, but also promotes tertiary lymphoid structures associated with improved T cell infiltration.

Biochemical and transgenic analyses reveal that Petunia hybrida S3-RNase cytotoxicity is largely restricted by a stepwise ubiquitination and degradation pathway during cross-pollination.

This study investigates the roles of phenotypic plasticity and genetic adaptation in the rapid global spread of the weed Capsella bursa-pastoris through common garden experiments.

The paper shows that knocking down LC3 increases micronuclei by promoting mitochondria-to-micronuclei transition during nuclear development.

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

The paper determines the structure of an 80S-like ribosome assembly intermediate, revealing how Tsr1 and Dim1 coordinate to regulate Fap7 and enable quality control during ribosome maturation.

The paper uses electron microscopy to reveal structural details of cytonemes in Drosophila, showing their variable diameters and contents, including ER, mitochondria, and ribosomes.

The paper identifies three-way junctions as prone to misfolding during ribosome assembly and shows how assembly factors and snoRNAs chaperone their folding to prevent kinetic trapping.

This study identifies Il13 enhancers that mediate gene transcription in response to antigenic stimulation by analyzing histone modifications and transcription factor binding sites.

The paper introduces a method to measure single-cell cytoskeletal protein complex expression heterogeneity and finds some cells upregulate other cytoskeletal complexes in response to stress.

This case study investigates the feasibility of direct EMG control of a powered ankle prosthesis combined with physical therapy training to improve postural control in a transtibial amputee.

The paper establishes reference values for liver diffusion MRI parameters in middle-aged subjects and shows age and gender effects, with IVIM modeling indicating perfusion is constrained by diffusion.

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

The paper investigates whether gain-of-function mutations in KCNQ1 cause super-trafficking of the potassium channel to the plasma membrane, finding increased surface levels and altered channel activity.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This study identifies AXL as a key driver of cell plasticity and metastasis in pancreatic cancer using single-cell RNA sequencing and mouse models.

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.

The paper identifies FZD7 as a marker of platinum-tolerant ovarian cancer cells that are susceptible to ferroptosis via the FZD7-β-catenin-Tp63-GPX4 pathway.

This study demonstrates that minor groove binders can protect wireframe DNA origami from endonuclease degradation, enhancing their stability in biological environments.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.