H. Liu

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

The paper investigates how plant and soil microbial diversity contribute to ecosystem functions in grasslands, finding they have unique and interactive effects under different aridity conditions.

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

This study reports the cryo-EM structure of the TOC-TIC supercomplex from Chlamydomonas reinhardtii, revealing its architecture and potential preprotein translocation pathways.

This study identifies new Bd lineages in China and finds sub-lethal effects on amphibians, supporting Asiatic origins of the pathogen.

This study shows SMARCAL1 loss-of-function mutations enable ALT in telomerase-negative glioblastoma cells, promoting tumorigenesis and telomere maintenance.

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

This study improves the InflectSSP pipeline for Thermal Proteome Profiling to enhance sensitivity and specificity in detecting proteome changes, demonstrating its effectiveness through reanalysis of datasets and a new UPR study.

This study identifies heterotrophic bacteria as key drivers of sulfur oxidation in coastal sediments and seawater by analyzing microbial communities and metagenomes.

The paper introduces a method combining algorithmic design, photoclick chemistry, and multi-material printing to rapidly create complex structures for biomedical applications.

This paper develops a kinetic model for solid waste treatment units using system dynamics and simulation, demonstrating its validity through a 370-day experiment with a prototype.

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

This paper introduces a hybrid fabrication method combining volumetric printing and two-photon ablation to create multiscale vasculature-like structures for organ-on-a-chip applications.

The paper investigates the association between oral bacteria in feces and gut microbiota depletion, supporting the Marker hypothesis over the Expansion hypothesis.

This study identifies BUD31 as a splicing factor that promotes ovarian cancer by maintaining anti-apoptotic BCL2L12 expression through exon inclusion.

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.

This study shows that PTH regulates bone formation by suppressing Zfp467 through cyclic AMP/PKA pathway, enhancing Pth1r transcription and osteogenesis.

The paper presents cryo-EM structures of bombesin receptors bound to their neuropeptide ligands, revealing the mechanism of ligand selectivity and receptor activation for itch treatment.

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.

This study shows that pre-activating γδT cells with IL-12/18/21 enhances their anti-tumor activity and overcomes resistance to anti-PD-L1 therapy in mouse models.

The paper analyzes marmoset monkey vocalizations to show that call patterns encode emotional states and transmit emotion between individuals.

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.