H. Liu

This study develops a vesicle-based method to determine membrane protein structures in their native lipid environment, demonstrating it with the AcrB transporter and showing a different assembly state compared to detergent-solubilized forms.

This study investigates how Clostridium bovifaecis, an FDH-lacking acetogen, uses formate as the sole carbon source for acetogenesis by converting it to acetate with a 2.0:1 to 2.6:1 molar ratio.

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

This paper introduces a new method for isolating and transforming passion fruit protoplasts, achieving high yield and transfection efficiency for transient gene expression.

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

This study identifies and characterizes bacterial P450 enzymes that catalyze post-translational macrocyclization of peptides, expanding the known functional capabilities of P450s.

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

This study identifies RLCK-VII subfamily members as essential for ROS production and signaling downstream of the Cf-4 resistance protein in N. benthamiana.

This study improves targeted insertion in plants using chemically protected dsODNs with 5' 1-nt overhangs, achieving directional and precise insertions for gene tagging and cis-regulatory engineering in Setaria viridis and rice.

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

This study compares interactions of Aspergillus fumigatus with A549 and HSAE cell lines, revealing distinct endocytosis and inflammatory responses.

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

This study identifies SERPINB3 as a marker for the basal-like/squamous subtype of pancreatic cancer, showing it promotes invasion, metastasis, and metabolic reprogramming.

The paper identifies bacterial peptidoglycan as a food signal in C. elegans that activates digestion by inhibiting UPRmt through interaction with BCF-1.

This study compares lysine-based and site-specific protein immobilization methods in single-molecule force spectroscopy, finding that lysine-based methods degrade signal quality and alter unfolding pathway classification.

The paper shows that the D2 region of CAMSAP3 binds to and expands microtubule lattices, stabilizing microtubules and explaining CAMSAP3's unique function.

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

This study investigates the role of ALOX15 in lung adenocarcinoma, finding that its downregulation correlates with tumor differentiation, proliferation, and metastasis, and that overexpression inhibits cancer cell growth.

The paper develops Brainoware, a living AI hardware using 3D brain organoids to compute nonlinear equations and demonstrate learning capabilities.

This study shows that stochastic processes dominate soil fungal community assembly in Populus davidiana forests, with elevation having a greater impact than seasonality.

The paper compares antigenic drift and viral fitness between two H1N1 clades, A5a.1 and A5a.2, finding that A5a.2 had reduced viral fitness despite similar or greater antigenic drift.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study investigates how wheat microbiomes respond to Fusarium pseudograminearum infection, showing significant changes in belowground microbial communities and their correlation with plant defence signalling.

This study shows that KDM5C, an X-linked demethylase, promotes energy metabolism in osteoclasts to regulate female bone mass, offering a new target for osteoporosis treatment in women.

This study identifies a multi-receptor complex involving c-Met, E-cadherin, and EGFR that C. albicans uses to invade oral epithelial cells, with Hyr1 and Als3 facilitating this process and dual inhibition of c-Met and EGFR reducing virulence.