H. Liu

This study shows that Cdk11 promotes centromeric transcription to maintain cohesion during mitosis by phosphorylating RNAPII.

This study identifies FOXM1 as a transcription factor that specifies and loads chromatin DNA fragments into extracellular vesicles via an LC3-dependent autophagosome-MVB pathway.

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

This study identifies Prom1 and Notch as regulators of ciliary length and dynamics in multiciliated airway epithelial cells, contributing to mucociliary clearance and lung defense.

This study characterizes GR13 plasmids in Acinetobacter, showing their capacity to accumulate and horizontally transfer diverse accessory genes through dif modules and insertion sequences.

The paper uses FRET sensors to study conformational changes in mGlu2 receptors, showing ligands modulate activation through multiple states.

The paper identifies sulfane sulfur-mediated post-translational modification of AdpA in Streptomyces coelicolor, enhancing actinorhodin production and morphological differentiation.

This paper demonstrates that non-T-cell based antigen depletion can induce apoptosis in CD19-expressing cancer cells, proposing a universal cellular therapy strategy using artificial antigen-recognizing cells.

This study investigates how age-matching between fecal microbiota transplantation (FMT) donors and aged recipients affects microbiota establishment and resilience, finding that mismatched age may reduce resilience against inflammation.

The paper constructs an ordered mutant collection of Bacteroides thetaiotaomicron using transposon-insertion and barcode sequencing, identifies factors limiting coverage, and demonstrates phenotypic screening for growth defects and cell shape changes.

The paper isolates and characterizes ultrahigh-affinity nanobodies from a camelid immunized with SARS-CoV-2 RBD, showing broad sarbecovirus neutralization and structural insights.

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

The paper identifies a YYDRxG motif in antibodies that broadly neutralize SARS-CoV-2 variants and related viruses, suggesting a conserved epitope targeting strategy.

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

This study shows that inactivating AMPK in medulloblastoma models slows tumor progression by reducing tumor stem cells and mTORC1 activity.

The paper shows that PncA from bacteria improves diet-induced NAFLD in mice by enhancing NAD+ synthesis and affecting lipid metabolism.

This study identifies 301 host factors in Salmonella involved in phage resistance, reveals cross-resistance mechanisms between RpoS and RpoN, and shows additional constraints define phage host range.

The paper develops and improves a coarse-grained force field for proteins and peptides, showing good performance in simulating membrane protein behavior and interactions.

This study shows that as mutualistic networks shift to antagonistic, indirect effects weaken, leading to less trait integration and faster adaptation in communities.

This study identifies Zfp335 as a transcription factor regulating T cell development by controlling TCRβ expression and cell survival through β-selection-dependent and -independent mechanisms.

The paper compares replication of H1 LAIVs with different HA and M2 sequences in human nasal epithelial cells, finding HA differences impact replication and immune response.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.

The paper identifies a PHYB-PIF4-MYC2 module that regulates secondary cell wall thickening in Arabidopsis under shaded light conditions.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

The paper proposes a deep learning algorithm for detecting hollow heart in potato tubers using consumer-grade hardware, achieving improved classification performance compared to human scoring and X-ray methods.

This paper identifies serum proteins that mediate endothelial cell invasion by non-C. albicans Candida species through bridging molecule-mediated endocytosis.

This study develops two PROTACs targeting NAMPT, showing they degrade the protein more effectively than FK866 in tumor cells, highlighting PROTACs as a better strategy for dual-function proteins.

This study isolates a panel of broadly neutralizing antibodies against SARS-like viruses from donors, showing effectiveness against multiple variants including Omicron.