H. Wu

The paper identifies small molecule fragments that bind to the tudor domain of SETDB1 and describes their binding modes and biophysical properties.

This study shows TRIM21 and PHLDA3 regulate cross-talk between PI3K/AKT signaling and PPP metabolism, with implications for cancer therapy.

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.

IL-2 mutein treatment expands multiple sub-states of Tregs with superior suppressive function in mice.

The paper models leukemia transcriptome dynamics in a state-space to identify critical points that predict disease development.

This study shows that G9a inhibitors reactivate maternal PWS genes in patient-derived neural cells and induce downstream PWS-related genes without altering DNA methylation at the PWS-IC.

The paper identifies a direct mechanical signal transfer pathway between β1 integrin, CD98hc, and TRPV4 channels that mediates ultra-rapid transmembrane mechanochemical conversion in focal adhesions.

This study identifies androgen-dmrt1 positive feedback as a mechanism driving sex reversal in rice field eel by analyzing gene regulation and enzyme expression.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This study shows that two redundant maize SCARECROW genes regulate mesophyll and endodermal cell layer patterning in leaves and roots, respectively.

The paper shows that human cells re-entering the cell cycle from quiescence have impaired p53-dependent origin licensing and slow MCM loading, leading to underlicensed first S phases and increased replication stress sensitivity.

This study identifies persistent B-cell clones in the cerebrospinal fluid of MS patients despite treatment, suggesting therapy-resistant immune mechanisms in the central nervous system.

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.

The paper compares the sensitivity of four probe technologies to measure biomechanical properties of different cellular regions in two cell types under various perturbations.

This study identifies FoxM1 as a key driver of proximal tubule proliferation during repair from acute kidney injury, revealing an EGFR-FoxM1 signaling pathway.

This study presents the structure of FtsX's extracellular loop and shows its essential interaction with PcsB for cell viability in Streptococcus pneumoniae.

This study shows lactate dehydrogenases (LDHA and LDHB) can both generate and prevent reactive oxygen species (ROS) in cancer cells, depending on oxidative stress levels.

This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.

This study compares the microbiome of Schlechtendalia chinensis aphids on two host plants, finding distinct bacterial communities associated with each host.

The paper identifies and maps the stripe rust resistance gene YrTZ2 in wild emmer wheat and compares its genomic region with Aegilops tauschii.

The paper identifies residues critical for allosteric activation in a bacterial repressor by analyzing ZnII-induced changes in atomic motions.

This study investigates the functional differences between two kinesin-2 proteins in trypanosomes, showing TbKin2a's role in IFT, cell division, and motility, while TbKin2b has a less critical role.

The paper investigates how membrane tension gradients and spatial variations in membrane properties influence cell shape and movement in a fluid environment.

This study shows that preexisting antibodies can prevent congenital cytomegalovirus infection in monkeys by blocking placental transmission.