H. Wu

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

This paper develops a multiplex immunoassay to measure SARS-CoV-2 antibody responses and finds that severe COVID-19 is associated with higher early antibody levels against S1 and N proteins.

This study uses a computational model to show how disordered domains of H1 linker histone restrict chromatosome dynamics and enhance its structural rigidity.

This study uses graph theory to analyze how intranasal oxytocin affects frontal brain network properties and links these changes to personality traits.

The paper develops a mathematical model to explain cross-species differences in myofibroblast effects on cardiomyocytes, identifying transient K+ currents as a key factor.

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.

The paper develops a ratiometric voltage indicator by fusing an improved red fluorescent protein to ASAP3, enabling motion artifact-free voltage imaging in motile cells.

This study identifies DPP9 as a repressor of NLRP1 inflammasome activation by sequestering the NLRP1 C-terminus, preventing inflammation during protein turnover.

This study examines the relationship between motor fitness, fundamental movement skills, and functional movement screen in primary school children, finding weak correlations and suggesting independent systems in motor development.

This study examines the interannual variability of net ecosystem carbon production in a rain-fed maize ecosystem, identifying climatic and biotic factors influencing carbon dynamics from 2005 to 2018.

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This study reports cryo-EM structures of NLRP1-CT and CARD8-CT inflammasome assemblies, revealing unique filament formation mechanisms and ASC recruitment specificity.

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

This study shows BMPER deficiency leads to insulin resistance and hyperglycemia, and BMPER therapy improves these conditions in mice.

This paper introduces a mass spectrometry-based method to directly detect non-natural sugars in glycopeptides, enabling the study of dynamic glycosylation without metabolic tagging.

The study introduces a new PET radiotracer for profiling tumor protein oxidation as a prognostic indicator of resistance to radiation therapy.

This study develops a multiplex immunoassay using serum and MENSA to diagnose active CDI, finding that combining both methods improves detection compared to using either alone.

The paper investigates how STAT1 activity in adipocytes affects insulin sensitivity in obesity, finding that STAT1 deletion improves mitochondrial function but does not resolve insulin resistance.

This study evaluates genomic predictive ability for wood properties in Norway spruce, finding that using 80-90% of data as training sets yields high accuracy, and that predicting young trees from older coring data is feasible.

The paper identifies two genes in Populus deltoides that antagonistically regulate sex determination by repressing female structures and promoting male structures through epigenetic and RNA-based mechanisms.

This study identifies common and subtype-specific GRHL2 binding sites in luminal-like and basal A breast cancer cells using ChIP-seq, revealing conserved DNA-binding motifs and absence of binding at EMT-related gene promoters.

This study shows hesperetin reduces foam cell formation in macrophages by activating LXRα through AMPK-dependent mechanisms, enhancing cholesterol efflux and reducing cholesterol accumulation.

This study identifies Ubp6 and Ubp3 as deubiquitinases that regulate protein quality control by modulating ubiquitin levels and degradation pathways in yeast.

This study identifies a PAF1C-dependent pathway that restores transcription elongation after DNA damage repair in human cells.

This paper identifies functional noncoding SNPs and their molecular mechanisms for 19 autoimmune diseases using multi-omics data and prioritizes drug targets.

This study examines how zinc and calcium ions affect the structure and mechanics of vimentin intermediate filaments, showing that zinc is more effective at lower concentrations and that ion binding can compete.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This paper reconstructs a genome-scale metabolic network for Mycobacterium leprae to study its metabolism and identify potential drug targets.

The paper identifies a lipid bilayer stress sensing mechanism in the UPR transducer Ire1 and shows it activates divergent transcriptional programs in yeast and C. elegans.