H. Zhang

This study shows Prochlorococcus emerged in deep Tonian oceans, enhancing oxygen production and displacing other bacteria, contributing to Neoproterozoic oxygenation.

This study shows vitamin D reduces ecDNA in hepatocellular carcinoma by stabilizing DNase1L3 via its transporter GC, leading to tumor suppression.

This study identifies shared inner membrane transporters for PQS-Fe3+ and PCH-Fe3+ in P. aeruginosa and shows their role in iron uptake and virulence.

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

The paper constructs a single-cell expression atlas of gill tissue in deep-sea mussels to study the molecular function and developmental trajectory of bacteriocytes and their interaction with endosymbionts.

This study identifies Ser149 as a 14-3-3 epsilon binding site on Cdc25B, showing its role in regulating G2/M transition in mouse fertilized eggs through phosphorylation and subcellular localization.

The paper introduces a biohybrid transition microelectrode array for neural recording and modulation, aiming to improve biocompatibility and functionality through organic materials.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

This study develops nanoPDLIM2, a PDLIM2-expressing nanoparticle, which enhances PD-1 blockade and chemotherapy efficacy in lung cancer by reactivating tumor immunity and reducing drug resistance.

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

The paper challenges the conclusion that microbial carbon use efficiency is the main driver of soil carbon storage, highlighting potential biases in previous analyses.

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.

The paper introduces aSRRF, a method that enhances SIM resolution to ~50 nm isotropically using image augmentation without changing the optical setup or sample acquisition.

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

The paper tests nucleoside analogues for antiviral activity against orthopoxviruses, finding tenofovir and adefovir effective with low toxicity.

This study investigates how SpRY-Cas9 recognizes DNA targets without requiring a PAM sequence, revealing structural and kinetic mechanisms that improve genome editing versatility.

This paper develops a multifunctional nanoplatform combining NIR-II imaging and targeted drug delivery for breast cancer treatment using EGF-modified PLGA nanoparticles.

The paper identifies SOFTI, a specific inhibitor of SPY O-fucosyltransferase, through virtual screening and validates its effects on O-fucosylation in Arabidopsis and tomato.

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

This study identifies host genetic and immune factors that determine susceptibility to E. coli liver abscesses in mice using spatial and single-cell transcriptomics.

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

This study shows that Ackr1-deficient mice have lower mortality from SARS-CoV-2 infection, suggesting ACKR1 may contribute to COVID-19 immunopathology and could be a drug target.

The paper shows that sterilized soil intake reduces asthma inflammation in mice by altering gut microbiota and shifting immune responses toward Th1.

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

This study identifies FOXK2 amplification and overexpression in breast cancer, showing its role in promoting tumor growth, chemoresistance, and synergistic therapeutic responses when targeted with PI3KCA inhibitors.

The paper compares placental transcriptomes and histology between native Tibetans and Han migrants, finding sex-biased expression divergence and adaptive histological changes in male-infant placentas.

The paper identifies two networks of TCRβ and IGH clonotypes with conserved CDR3 sequences associated with over 63 diseases, suggesting evolutionary-conserved primordial antigen receptors.

The paper identifies the iol gene cluster in Pseudomonas as a conserved feature linked to root colonization and host-microbe interactions, suggesting it as a target for improving bioinoculants.