J. Cheng

This study evaluates the efficacy of a vaccine regimen using wildtype and Beta variant S-2P in hamsters against SARS-CoV-2 Delta and VoCs, showing improved neutralization and protection with a mixed-dose schedule.

This study identifies shared and unique cellular responses to moderate and acute high temperatures in Chlamydomonas reinhardtii, revealing mechanisms for thermotolerance.

This study uses silica-dried leaf tissues for RNA-seq and phylotranscriptomic analysis, showing they are viable for phylogenomic studies with results comparable to liquid nitrogen-preserved samples.

This study identifies pheromone receptors in Cnaphalocrocis medinalis that enable it to detect conspecific and heterospecific pheromones, aiding in avoiding competition in rice fields.

This paper develops a line scanning SMLM system for tissue imaging, revealing nonrandom nuclear pore distribution in Drosophila tissues, contrasting with cultured cells.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

The paper solves cryo-EM structures of human 39S pre-ribosomes to reveal late assembly intermediates and factors involved in mitoribosome formation.

This paper compares deep learning and machine learning approaches for decoding motor intent from nerve signals, finding that deep learning offers better accuracy with large data while machine learning is more efficient with smaller datasets.

This study shows that polyQ expansion in HTT does not change the structure of the HTT-HAP40 complex, as revealed by biophysical and cryo-EM analyses.

The paper identifies Olfr109 as an olfactory receptor that detects insulin peptides in pancreatic β cells, modulating glucose metabolism and inflammation.

The paper introduces WIAD, an open-source tool for visual analysis of wood images to improve transparency and reproducibility in ecological studies.

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

This study compares sentiment and network structures around vaccines and climate change on Twitter using machine learning, finding less polarization in vaccine discussions and a link between pro-vaccine sentiment and belief in anthropogenic climate change.

This study uses cryo-electron tomography to compare 3D subcellular structures of wild-type and mutagenic Chlorella pyrenoidosa strains, revealing structural changes linked to increased growth rates.

This study reports the first systematic analysis of aphid and parasitoid wasp species composition and dynamics in maize fields of Jilin Province, China, over two years.

This paper develops a bioelectric neural interface using implantable electrodes and AI to enable intuitive control of a high-DOF prosthetic hand for amputees.

This paper introduces a method to determine in situ structures using single particle cryo-EM images without tilt series, improving efficiency and resolution.

This paper develops a subunit vaccine against COVID-19 using CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen and shows it induces high neutralizing antibody titers and Th1 response in mice.

This study identifies site-specific O-glycosylation patterns in SARS-CoV-2 spike proteins, revealing host-dependent variations and their potential implications for viral function and therapeutic development.

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

This study identifies the c-Met/β1 integrin complex as a driver of breast cancer intravasation and bone metastasis, suggesting therapeutic targeting could prevent metastases.

This study develops and evaluates porous scaffolds combining HA, PLGA, and MSM for bone defect reconstruction, showing improved cell adhesion, proliferation, and drug release properties.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

This study identifies CD22-dependent SHP-1 regulation of β7 integrin expression, showing its role in intestinal immunity and pathogen clearance.

This study describes a method to expand pancreatic islet clusters in vitro using hormones and chemicals, resulting in functional islet-like structures with cell type markers.

This study shows RTR-1, a compound from Rhodomyrtus tomentosa, inhibits gastric cancer cell proliferation by inducing ER stress and blocking the STAT3 pathway, while causing G2/M phase cell cycle arrest.

The paper uses PALM to show SBF/MBF transcription factors form clusters in yeast cells, with cluster number increasing as cells grow.

This study identifies molecular mechanisms of translational stalling caused by inhibitory codon pairs and poly(A) tracts using in vitro biochemistry, ribosome profiling, and cryo-EM.

This study shows TRIM21 and PHLDA3 regulate cross-talk between PI3K/AKT signaling and PPP metabolism, with implications for cancer therapy.