J. Huang

This study uses molecular dynamics simulations to reveal the Na+-driven transport mechanism of bile acid by hNTCP, identifying key binding modes and conformations.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

The paper develops an mRNA vaccine to predict brain tumor response to checkpoint inhibitors by analyzing cytokine release patterns in vitro.

This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.

This study identifies galectin-3 as a factor that inhibits mitochondrial function and causes cell cycle arrest in CD8+ T cells of severe/critical COVID-19 patients, with potential therapeutic implications.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

This study uses 3D bioconjugated liquid-like solids to model tumor-immune interactions, showing CAR T cells can infiltrate and kill cancer cells while revealing immune escape mechanisms.

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

This study shows that loss of p53 and RB in mouse cells leads to epigenetic changes and upregulation of transposable elements, suggesting they work together to suppress transposons and prevent tumorigenesis.

This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

This study generates human alveolar epithelial type I cells from iPSCs by activating YAP signaling, revealing Hippo-LATS-YAP's role in their differentiation.

This study develops a deep learning model to classify hematopoietic stem cells and multipotent progenitors using light microscopy images, demonstrating its effectiveness in distinguishing functional subpopulations.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

The paper analyzes RNA-seq and scRNA-seq datasets to identify immune cell interactions in the testicular microenvironment of azoospermia patients, finding altered monocyte/macrophage signaling patterns.

This study shows that the ESCRT pathway and MVBs are essential for trap formation in the nematode-trapping fungus Arthrobotrys oligospora in response to ammonia.

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

This study identifies a signaling cascade involving GxcM, Fbp17, RacC, and WASP that regulates rear cortical actin assembly in migrating Dictyostelium cells.

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

The paper investigates how sub-threshold odor mixtures mask the unpleasant smell of iso-valeric acid using Sniff Olfactometry, finding that mixtures reduce recognition by up to 96%.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

This study shows that senescence in CD8+ T cells reduces VLA-4 expression, impairing their migration and promoting leptomeningeal metastasis in a mouse model of breast cancer.

This paper develops an amplified lateral flow assay for at-home SARS-CoV-2 testing with improved sensitivity compared to commercial assays.

This paper develops a visual perception system using pose estimation to analyze fish swimming and provides code and dataset for the method.

The paper identifies parallel amino acid substitutions at the Rdl gene in insect pests and their parasitoid wasps, showing how resistance to insecticides evolves in both species.