J. Lee

This study shows Group A Streptococcus (GAS) persists in macrophages by inducing lysosomal dysfunction through membrane perforation and blocking acidification.

This paper identifies sex-specific niche signaling differences in hematopoietic regeneration following stem cell transplantation and shows exogenous sex hormones regulate hematopoietic stem and progenitor cells.

This study identifies Prdx5's role in bone regeneration by regulating osteoblast differentiation through interaction with hnRNPK, impacting osteocalcin expression and osteoclast activity.

This paper introduces a platform integrating phenotypic screening and metabolomics to improve mechanism of action prediction for natural products, leading to the discovery of novel bioactive compounds.

This study identifies RhCMV-specific induction of FcRγ-deficient NK cells in rhesus macaques, with co-infections enhancing their frequency.

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

This paper describes the development and outcomes of a plastic surgery summer research program for first-year medical students over seven years, showing increased research productivity and residency match in plastic surgery.

This study generates human heart organoids with cardiac morphology and electrophysiological properties using optimized culturing conditions.

The paper visualizes the nuclear matrix and intranuclear compartments using super-resolution microscopy, revealing their layered distribution and role in transcriptional regulation.

This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.

This study identifies biomarkers beyond B7H3 expression that predict response to a B7H3-ADC in metastatic prostate cancer models, improving therapeutic efficacy.

This study shows that the RelA TAD increases NFκB-DNA binding affinity but reduces specificity for κB sequences by enhancing non-specific DNA binding.

The paper develops a scoring model to assess protected species vulnerability and site suitability for aquaculture in the Gulf of Mexico using multi-criteria decision-making for marine spatial planning.

This study characterizes the kinetic and redox properties of KRASG12C inhibition, revealing pH-dependent covalent ligation and oxidation effects on protein conformation.

This study evaluates the neutralizing activity of nine anti-SARS-CoV-2 monoclonal antibodies against variants of concern and reveals their structural mechanisms of action.

clampFISH 2.0 enables rapid, scalable detection of multiple RNA species in single cells and tissue sections by improving signal amplification and reducing time and cost.

This paper evaluates a pulse-interval modulation (PIM) communication scheme for wireless brain-machine interfaces, finding it reduces power consumption while maintaining accurate neural signal transmission.

This study identifies how residual triple negative breast cancer cells adapt mitochondrial structure and function to survive chemotherapy, showing that DNA-damaging agents promote mitochondrial fusion and OXPHOS, which can be targeted with OPA1 inhibitors.

This study identifies QTLs underlying flowering time adaptation in common ragweed during its European invasion, revealing a concentrated genetic architecture with suppressed recombination in specific genotypes.

This study shows retrons can generate donor DNA for HDR gene editing in human cells, achieving up to 11.3% HDR efficiency when combined with CRISPR-Cas9.

This study shows that beta-cell Cre expression and reduced Ins1 gene dosage protect NOD mice from type 1 diabetes, with Cre itself contributing additional protective effects.

This study shows that LAG3 deficiency in mice leads to rapid rejection of kidney allografts via antibody-mediated rejection, highlighting LAG3's role in regulating anti-donor humoral immunity.

The paper describes synthetic glycans that alter gut microbiome structure and reduce colitis in mice by selectively affecting bacterial growth and metabolism.

This study shows PEGPH20 improves radiation therapy efficacy in pancreatic cancer tumors with high hyaluronan by increasing oxygenation, as measured by multiple imaging techniques.

This study shows that BsCsp3 stores Cu(I) in the cytosol for BsCotA in B. subtilis during sporulation, challenging the dogma that bacteria avoid intracellular Cu storage.

This study shows PTHrP overexpression in mammary epithelial cells promotes secretory differentiation and accelerates breast tumor progression through STAT5 activation.

This study identifies MSD2, an apoplastic Mn-SOD in Arabidopsis, showing it modulates ROS distribution in roots during skotomorphogenic growth.

The paper compares EV isolation methods using Simoa assays to quantify EV markers and assess efficiency and purity in plasma and CSF.