J. Lee

The paper compares DNA and RNA microbial communities in Miscanthus x giganteus soil under different nitrogen fertilization rates, finding RNA-based communities better reflect nitrogen-cycling taxa.

The paper identifies a cytoskeletal vortex in E. coli jumbo phage Goslar that drives phage nucleus rotation, similar to eukaryotic structures.

This study shows Mitoxantrone inhibits SARS-CoV-2 infection by targeting the spike-GAG complex, but also affects nucleosome dynamics.

The paper uses taxonomic classification methods to identify a new subgenus in the Orthoparamyxovirinae subfamily based on viral genome sequences from bats.

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

This study examines cardiotoxic effects of methamphetamine in zebrafish, finding increased heart rate but not QTc prolongation, along with myocardial damage and gene expression changes.

The paper reports high-resolution crystal structures of a C1 domain bound to DAG and agonists, revealing mechanisms of lipid recognition and guiding drug design.

This study shows Drosophila centrocortin is not needed for centriole duplication but helps with centrosome separation during mitosis.

This study shows that Bmal1 regulates the rhythmic cell cycle progression and lipid accumulation in hepatocytes during liver regeneration, with disruptions in Bmal1 leading to delayed DNA synthesis, loss of mitotic oscillation, and altered redox state.

This study evaluates the in vitro activity of bedaquiline and imipenem against M. abscessus under different growth conditions, finding varying interactions between the drugs.

This study identifies ADAP1 as a factor that enhances T cell signaling and promotes HIV-1 reactivation by modulating the ERK-AP-1 axis.

This study identifies two distinct roles of CSP in protein quality control, showing that dysfunction leads to lipofuscin accumulation and neurodegeneration in a Drosophila model.

This paper creates a meta-atlas of human liver immune cells using scRNA-seq data to define immune homeostasis features and identify pathway differences across studies.

This study develops a novel ECG monitoring system for zebrafish to assess cardiovascular function and drug effects, showing improved efficiency and reduced side effects.

The paper extends CHARMM-GUI Membrane Builder to model and simulate lipid nanoparticles with ionizable cationic lipids and PEGylated lipids, showing how PEG-lipids affect membrane structure and dynamics.

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

This study develops dual-payload antibody-drug conjugates to overcome breast tumor heterogeneity and drug resistance, showing improved efficacy in a xenograft model.

This study identifies C. elegans pezo-1 as a mechanosensitive ion channel involved in food sensation by analyzing its expression, function, and mechanosensitivity through genetic and electrophysiological methods.

This study shows that Ascl1 activation in maternal liver during pregnancy supports healthy pregnancy outcomes by coordinating maternal organ adaptations and placental growth.

This study shows that Nrf2 deficiency leads to hepatocyte dedifferentiation and reduced albumin production in a cholestasis model.

This study delivers Notch Intracellular Domain plasmid via PLGA nanoparticles to upregulate Notch signaling in HUVECs, showing nontoxicity, stability, and successful gene expression.

This study develops a stem cell-laden hydrogel bioink that enables high-resolution and fidelity 3D bioprinting of complex tissue structures.

This study tests virtual prism adaptation therapy using a depth-sensing camera and fNIRS in healthy adults to assess behavioral and cortical changes during adaptation phases.

The paper evaluates the effectiveness of TMPRSS2 and RdRp inhibitors against SARS-CoV-2 variants B.1.1.7 and B.1.351, finding they are equally effective as against the original isolate.

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

The paper uses single-cell methods to explore the complexity of the mononuclear phagocyte compartment in the human intestinal lamina propria, identifying distinct subsets, site-specific signatures, and lineage-specific precursors.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

The paper identifies key receptor-like protein genes in pepper that confer broad-spectrum resistance by analyzing co-expression networks across multiple pathogen infections.