J. Li

This study examines how restricted feeding during gestation affects blood glucose levels and gut microbiota in sows across pregnancy and lactation stages.

The paper shows Belgian endive root extracts promote shoot and root growth in Arabidopsis and Plectranthus, with water-soluble sugars and malate as key bioactive compounds.

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

The paper presents a high-resolution cryo-EM structure of cyanobacterial photosystem I complexed with Cytochrome c6 and Ferredoxin, revealing binding interactions and a proposed electron transfer mechanism.

This study investigates how reducing chemical fertilizers and adding bio-organic fertilizer affects soil microbial communities and Baby Chinese cabbage yield in Gansu plateau, finding that T2 treatment yields the highest crop output.

The paper identifies a novel coronavirus in Swedish bank voles, showing repeated detection and phylogenetic placement in a divergent Embecovirus lineage.

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.

This study shows that heat-acclimated mice have more Tregs, which reduce inflammation and improve heat tolerance through the PD-1/PD-L1 pathway.

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This paper develops a computational model to simulate how mechanical stress influences cortical microtubule orientation and organization in plant cells, revealing key parameters that mediate stress-dependent patterning.

This study uses spatial transcriptomics and single-cell RNA-seq to analyze immune microenvironment changes in gastric cancer progression, identifying immune cell dysregulation and key signaling pathways.

This study examines the role of MMP12 and Calpain 1/2 in liver fibrosis resolution using a mouse model, finding that MMP12 inhibition delays resolution and Calpains may contribute to protein degradation.

This study shows that nitric oxide inhibits gibberellin signaling by S-nitrosylating RGA, balancing growth and salt tolerance in Arabidopsis under salinity stress.

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This study assesses the antiviral activity of remdesivir and GS-441524 against multiple SARS-CoV-2 variants, finding they remain effective against Delta, Omicron, and other variants.

The paper investigates how a bacterial pan-genome affects gene essentiality and shows that essential genes can evolve to become non-essential through genetic changes and mechanisms like functional redundancy and pathway rewiring.

This study shows that remdesivir resistance in SARS-CoV-2 develops slowly, with a single mutation conferring limited resistance.

This paper introduces a method to create autonomously regulated oxygen microenvironments in microscale cell cultures using an oil overlay, validated with simulations and experiments across multiple cell types.

The paper identifies a mutation in the SARS-CoV-2 Omicron variant's structural envelope protein that reduces ion channel calcium permeability and acid sensitivity, leading to lower cell damage and cytokine production.

This study constructs multiscale models of SARS-CoV-2 using coarse-grained molecular dynamics simulations and experimental data, revealing dynamic behavior of membrane proteins and lipid interactions.

The paper identifies IMC proteins in Plasmodium yoelii and shows DHHC2 palmitoylates CDPK1 and GAP45 for their localization, essential for schizont development.

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

The paper determines the crystal structure of the Caskin1/CASK complex, revealing the molecular basis of CASK_CAMK domain binding specificity and identifying new potential binding partners.

This study investigates how O-glycosylated N- and C-linkers regulate the affinity and stability of the A1 domain of von Willebrand factor for GPIbα, revealing differential effects on binding and structural dynamics.