J. Li

This study investigates the structural basis of SARS-CoV-2 Omicron variant's immune evasion and transmissibility using cryo-EM, revealing conformational changes and enhanced ACE2 binding.

This paper develops bright fluorophores and uses heavy water to improve fluorescence imaging of deep-buried hollow organs, achieving better visualization and diagnosis.

This paper develops a gene expression strategy that exploits neomorphic DNA-binding of fusion transcription factors in pediatric sarcomas to deliver therapeutic payloads with tumor-specific efficacy.

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

This study characterizes translocation renal cell carcinoma (tRCC) through integrated clinical and molecular analysis of 152 patients, identifying key features like MiT/TFE fusions, NRF2-driven antioxidant response, and differential treatment outcomes.

This study investigates how homoeologous exchange affects gene expression and alternative splicing in synthetic allotetraploid wheat, finding cis- and trans-regulatory impacts on gene expression and AS events.

This study shows that IL4 signaling in macrophages promotes lung metastasis by enhancing tumor cell extravasation and regulating pro-tumoral gene expression.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

This study uses direct RNA sequencing to analyze RSV mRNA transcripts in infected cells, revealing gene abundance patterns and polyadenylate tail lengths.

The paper identifies KIR+CD8+ T cells as regulatory cells in humans that suppress pathogenic CD4+ T cells in autoimmune and infectious diseases.

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

This study develops a metabolitin-based drug delivery system targeting GPR158 in glioblastoma, showing BBB penetration and anti-tumor effects in vitro and in vivo.

This paper shows suramin neutralizes histones, preventing endothelial damage and improving vascular function in inflammatory conditions.

This study identifies increased chondroitin sulfate proteoglycan levels in fibrolamellar carcinoma through gene expression, mass spectrometry, and single-cell sequencing.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This paper develops a vascular bundle detection model for Phyllostachys and finds consistent radial gradient patterns across 29 species.

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

The paper shows Mtb-infected mice are resistant to secondary SARS-CoV-2 infection without affecting Mtb levels, linked to T and B cell expansion in the lungs.

This study shows that TNF-α-stimulated BMSCs reduce oxidative stress and tissue damage in fatty liver IRI in rats.

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.

This paper identifies a novel pectin from Syzygium aromaticum that strongly inhibits SARS-CoV-2 replication by binding to 3CLpro, PLpro, and RdRp enzymes.

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This study shows that disrupting Golgi structure by knocking out GRASP55 and GRASP65 alters glycosaminoglycan synthesis, sulfation, and secretion.

The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.

This study shows macaque monkeys use strategy-based hierarchical decision-making to play Pac-Man with over 90% accuracy, revealing advanced cognitive capabilities previously unobserved in animals.

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

This study identifies PplD as a de-N-acetylase that modifies the cell wall linkage unit of streptococcal rhamnopolysaccharides, enhancing resistance to host antimicrobial proteins.