J. Li

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

This study shows that combining TBX18 gene transfer with Tgfβ inhibition sustains biological cardiac pacing in rats beyond four weeks.

IDPConformerGenerator generates diverse ensembles of disordered protein states using physical restraints and machine learning, enabling structural analysis of intrinsically disordered proteins.

This study shows p53 suppresses tumors by promoting TREX1 degradation, leading to cytosolic DNA accumulation and activation of the cGAS/STING pathway, which induces type I interferons.

This study identifies GPR151 as a regulator of hepatic gluconeogenesis and links its dysfunction to type 2 diabetes risk.

The paper identifies AIM2 and IFI16 as autoantigens in SLE that bind NETs, leading to DNase-resistant structures that promote sustained IFN signaling.

This study identifies myostatin upregulation in paravertebral muscle cells as a driver of oxidative stress and apoptosis, contributing to idiopathic scoliosis development.

This study identifies Rho1 as a key regulator of egg size plasticity in honey bees, showing queens adjust egg size based on colony size through molecular changes involving energy metabolism and cytoskeleton functions.

This paper designs a DNA-based photoswitch that enables rapid and reversible control of aptamer binding activity through azobenzene isomerization.

This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.

This study shows that a neurogenic hydrogel can regenerate radiation-damaged salivary glands in mice, restoring saliva production over three months.

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

The paper examines intraspecies diversity and evolutionary patterns of microbial populations in deep sea cold seep sediments, finding depth-dependent diversification and purifying selection on key metabolic genes.

habCluster identifies geographical boundaries of intraspecific units using a community detection algorithm, showing good alignment with nature reserves for giant pandas.

This study identifies conserved CAF subtypes in human and mouse breast tissues and reveals shared molecular mechanisms in their transition from normal stromal cells.

This study shows that AtSWEET13 and AtSWEET14 transport sucrose, not GA, which is critical for pollen viability and germination during late anther development.

This study shows hypoxia drives an inflammatory phenotype in pancreatic cancer-associated fibroblasts, promoting tumor IL1 expression and iCAF formation in hypoxic regions.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

This study identifies the genetic architecture of grain size and weight in barley using a multi-parent population, revealing complex QTLs and novel regulators.

The paper shows that APC/C-Cdc20-dependent degradation of Clb4 is required for the anaphase switch in astral microtubule dynamics, crucial for spindle orientation.

The paper identifies a rare invasive subpopulation of melanoma cells that drives metastasis, independent of environment, through non-genetic gene expression fluctuations.

This paper describes a scalable method for producing high-quality recombinant three-finger proteins using E. coli, enabling their use as molecular probes.

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.

This study identifies myeloid HIF1A as a cardio-protective factor during ischemia and reperfusion, mediated by netrin-1 induction in neutrophils.

The paper shows that the Phage Nucleus of {phi}PA3 forms a self-assembling, 2D crystalline lattice with adaptable inter-tetramer contacts and functional channels.

This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

This study identifies a conserved PLK1 docking site in TopBP1 that is essential for maintaining genome integrity during mitosis, as its deletion increases DNA damage and mitotic errors.

The paper develops a 384-well CometChip platform for high-throughput DNA damage analysis and identifies 3-methyladenine as an enhancer of etoposide-induced DNA damage.