J. Xu

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

The paper investigates arsenite's effects on IL-1beta secretion, mitochondrial respiration, and myocardial ischemia-reperfusion injury in rats.

This study identifies TGFβ1-producing monocytes/macrophages as drivers of heterotopic ossification in a mouse model and shows CD47 activation can reduce HO by modulating these cells.

This study shows that loss of Tjp2 in hepatocytes and cholangiocytes leads to cholestatic liver disease and increased susceptibility to liver injury, with protective roles in regulating bile acid transporters and detoxification enzymes.

This study shows that Lfc/Arhgef2 regulates mitotic spindle orientation in HSCs and is essential for hematopoiesis, as its loss causes impaired hematopoietic recovery and HSC exhaustion.

This study identifies qKW9, a gene affecting maize kernel weight by regulating photosynthesis through C-to-U editing of NdhB.

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

The paper challenges the current model of ER stress sensing by showing ATF6 is sorted to the Golgi as a peripheral membrane protein, and translocon inhibition drives its activation.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

This study identifies MnJ, a colloidal manganese salt, as a potent universal adjuvant that induces both humoral and cellular immune responses, including CTL activation and mucosal immunity.

The paper identifies a lipid bilayer stress sensing mechanism in the UPR transducer Ire1 and shows it activates divergent transcriptional programs in yeast and C. elegans.

The paper reanalyzes experimental data to show that action potential propagation delays are small compared to signal duration, suggesting a new physical model for neural signal communication.

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

This study determines the structure of an E. coli transcription activation complex and shows that Crl stabilizes σS to activate transcription without DNA contact.

This study shows higher-order patterns improve NIS spread risk predictions in shipping networks compared to first-order models, highlighting differences between ballast and biofouling vectors.

APEX-seq maps subcellular RNA localization with nanometer resolution, revealing nuclear transcriptome organization and mitochondrial mRNA pathways.

This study identifies Di-Ras2 as an oncogene in ccRCC that promotes tumor formation by activating the MAPK pathway in the absence of VHL.

The study compares IL-1, TNF-, and P-selectin mRNA expression in porcine endothelial cells after vein thrombosis at different time points.

This study shows that TET1 and TDG reduce intestinal tumor formation by suppressing inflammatory and immune response pathways through DNA demethylation.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

This study identifies PD-1 palmitoylation, its regulatory enzyme, and develops a peptide inhibitor to target PD-1 expression for cancer immunotherapy.

This study shows pretomanid improves the efficacy of TB treatment regimens in mice by reducing relapse and bedaquiline resistance.

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

The paper shows hypotonic stress causes rapid, reversible vimentin cytoskeleton degradation via calcium release and calpain proteolysis, preceding changes in other cytoskeletal systems.

This study identifies a plasma circular RNA panel with higher diagnostic accuracy than AFP for detecting HBV-related hepatocellular carcinoma.

The study detects Wolbachia in wild Ae. aegypti mosquitoes from New Mexico and Florida, but not in Texas, and identifies the wAlbB strain.

This study examines how fungal communities in soil change along a forest disturbance gradient, finding declines in saprotrophic fungi and increases in pathogenic fungi, indicating shifts in soil nutrient limitations.