J. Yang

Noncanonical TRAIL Signaling Promotes Myeloid-Derived Suppressor Cell Abundance and Tumor Progression in Cholangiocarcinoma

This study shows that TRAIL+ cancer cells use noncanonical TRAIL signaling in MDSCs to promote their abundance and tumor progression in cholangiocarcinoma.

Tumor-specific neutrophils originating from meninges promote glioblastoma

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer

This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.

DeCOIL: Optimization of Degenerate Codon Libraries for Machine Learning-Assisted Protein Engineering

DeCOIL optimizes degenerate codon libraries for ML-assisted protein engineering to generate diverse and high-fitness protein variants.

Transcriptional changes consistent with altered neuronal differentiation, angiogenesis, and tumor plasticity induced in human subpallial telencephalic organoid-glioblastoma chimeras.

This study investigates reciprocal interactions between human subpallial telencephalic organoids and GBM spheroids, identifying transcriptional changes linked to neuronal differentiation, angiogenesis, and tumor plasticity.

Functional Relations of CSLD2, CSLD3, and CSLD5 Proteins during Cell Wall Synthesis in Arabidopsis

This study investigates the functional roles of CSLD2, CSLD3, and CSLD5 proteins in cell wall synthesis in Arabidopsis, showing their conserved {beta}-1,4 glucan synthase activities and distinct contributions to cell plate formation.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

A Nanoparticle RIG-I Agonist for Cancer Immunotherapy

This paper develops SLR-LNPs, a nanoparticle-based RIG-I agonist, showing enhanced tumor immunogenicity and improved response to immune checkpoint inhibitors in mouse cancer models.

Vacuolar H+-ATPase subunit a was identified as the target protein of the oomycete inhibitor fluopicolide

The paper identifies vacuolar H+-ATPase subunit a as the target of fluopicolide, an oomycete inhibitor, and suggests H+-ATPase as a novel fungicide target.

Disulfiram Exerts anti-pulmonary Fibrosis Effect by Activating PGE2 Synthesis

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

A CRISPR-drug perturbational map for identifying new compounds to combine with commonly used chemotherapeutics.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

Effect of Intermittent Pneumatic Compression on Preventing Deep Vein Thrombosis Using Microfluidic Vein Chip

The paper develops a microfluidic vein chip to simulate IPC effects and identifies optimal parameters for DVT prevention.

Toleration of Frameshift Mutations in mRNA Sequences Encoding the N-terminal Peptides of Bacterial Type III Effectors

The paper uses computational methods to analyze mRNA sequences of bacterial type III and IV effectors, finding that type III effectors show high frameshift tolerance in secretion signals, while type IV show low tolerance.

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus

The paper shows that quorum sensing in Staphylococcus aureus controls phage susceptibility by modulating receptor structures, and that cross-species communication with non-aureus staphylococci can protect S. aureus from phage infection.

Aged Breast Matrix Bound Vesicles Promote Breast Cancer Invasiveness

This study identifies aged breast matrix-bound vesicles (MBVs) that promote cancer invasiveness by altering miRNA and cytokine profiles in human mammary epithelial cells.

Mitochondrial GTP Metabolism Regulates Reproductive Aging

This study shows that mitochondrial GTP metabolism regulates reproductive aging in C. elegans by controlling mitochondrial dynamics and homeostasis.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

Poly(A) tail length regulation by mRNA deadenylases is critical for suppression of transposable elements

This study shows that RNA deadenylation by the CCR4-NOT complex is critical for suppressing transposable elements in Arabidopsis, independent of small RNA targeting.

Degenerated CRISPRs widely regulate Cas expression to balance immunity and cost

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

Machine learning reveals relationships between song, climate, and migration in coastal Zonotrichia leucophrys

This study uses machine learning to analyze White-crowned Sparrow songs and finds that song divergence correlates with environmental factors and migratory status, not geographic distance.

Comparative transcriptomics reveals divergence in pathogen response gene families amongst 20 forest tree species

This study uses RNA-seq data from 20 forest tree species to analyze gene family divergence, identifying shared whole genome duplication events and rapid evolution in pathogen response genes.

Spatiotemporal cell landscape of human embryonic tooth development

The paper maps the spatiotemporal cell landscape of human embryonic tooth development using single-cell RNA sequencing and spatial transcriptomics, identifying key cell types and regulatory networks.

CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth

This study shows that CXCR2 expression in melanoma progenitor cells drives tumor growth by altering transcriptional programs and immune responses.

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

Proliferating cell nuclear antigen involves in temperature stress tolerance of Ulva prolifera

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

Lower-limb Nonparametric Functional Muscle Network: Test-retest Reliability Analysis

This study evaluates the test-retest reliability of non-parametric lower-limb functional muscle networks in healthy subjects for controlled and lightly-controlled tasks.

Assessing the impact of successive soil cultivation on Meloidogyne enterolobii infection and on soil bacterial assemblages

This study evaluates how repeated soil cultivation affects Meloidogyne enterolobii infection and soil bacterial communities in two different agricultural soils over two experiments.