K. Wang

The paper reports that chimeric receptor proteins formed by fusing BIR3 LRR domains with SERK-dependent LRR-RK kinase domains activate signaling pathways constitutively, leading to gain-of-function phenotypes.

This study identifies BCAT2 as a suppressor of ferroptosis in cancer cells, showing its role in regulating glutamate levels and enhancing resistance to ferroptosis-inducing therapies.

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.

This study shows that MAPK-induced miR-29 suppresses melanoma by targeting MAFG, and its inactivation accelerates tumor development.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

The paper describes a novel Protomyces strain isolated from Arabidopsis phylloplane and shows it enhances plant immunity against Botrytis cinerea.

This study develops dihydroartemisinin-loaded magnetic nanoparticles to enhance chemodynamic therapy, showing improved ROS production and efficacy against breast cancer cells, including drug-resistant ones.

The paper isolates and characterizes a novel Protomyces species from Arabidopsis, re-examines genus classification, and proposes taxonomic revisions based on genomic and physiological data.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

This study identifies molecular and cellular differences between murine syngeneic tumor models and human tumors, highlighting limitations in using syngeneic models for immunotherapy research.

The paper shows that HR4Fei-0 disrupts RPP7bLerik1-3 oligomerization, triggering NLR signaling and cell death, while HR4Col-0 does not.

This paper characterizes the temperature dependence of hERG channel kinetics using a high-throughput protocol and finds that Q10 coefficients poorly represent the temperature sensitivity, while a generalized Eyring relationship fits better.

This paper introduces a 15-second high-throughput protocol to rapidly characterize hERG channel kinetics using automated patch clamp systems and validates it with a hierarchical Bayesian model.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This paper introduces MSMC-IM, a method to track human population structure through time using whole genome sequences, revealing deep ancestry in some African populations.

This paper identifies rare germline mutations associated with triple-negative breast cancer risk using a machine learning approach and shows improved risk prediction compared to existing methods.

The paper predicts optimal dosing gaps for BEV-PEM/CIS in mice and humans to maximize efficacy while minimizing toxicity.

This paper isolates and characterizes extracellular vesicles from C. elegans, showing they share key properties with mammalian EVs and enabling multi-omic analysis.

This study uses metagenomic sequencing to identify pathogens in culture-negative infective endocarditis cases, providing antimicrobial resistance profiles without culturing.

This study analyzes 255 chronic osteomyelitis patients in northern China, finding higher prevalence in males aged 41-50, common infection sites, and better outcomes with two-stage debridement and antibiotic-loaded PMMA beads.

This study shows that sublancin enhances macrophage function and protects mice from MRSA infection by activating innate immunity and improving T cell responses.

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.

The paper analyzes genetic data from Yangtze finless porpoises to show population fragmentation, low genetic diversity, and recent decline linked to habitat degradation and human activity.

The paper develops a base-resolution m1A profiling method and identifies distinct m1A methylome classes in human nuclear and mitochondrial transcripts, showing functional roles in translation efficiency and mitochondrial mRNA regulation.

The paper introduces a method to map chromatin motions in live cells using structured illumination and finds correlated local motions and reduced diffusion during DNA damage.

This paper develops a serum-free culture method that maintains spontaneous and periodic contractions of intestinal muscularis cells from mice and humans for months, enabling studies of gut motility and regeneration.

This study identifies a Calcineurin-FoxO-MuRF1 signaling pathway that mediates Ca2+ overload-induced myofibril degradation in cardiomyocytes using zebrafish models.