L. Chen

This study investigates bone loss mechanisms in Winnie mice, a model for IBD, finding elevated gut-derived serotonin inhibits osteoblastogenesis through molecular pathway interactions.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

This study reports cryo-EM structures of the human DUOX1-DUOXA1 complex in different calcium states, revealing structural features and calcium regulation of its catalytic activity.

This study examines virulence evolution in multiple infections of fungal pathogens with different transmission modes in a natural plant system, finding that vertical transmission correlates with decreased virulence while horizontal transmission correlates with increased virulence.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.

This study investigates the effect of S100A8 and its recombinant form ala42S100A8 delivered via pluronic gel on reducing inflammation in mouse skin wounds, showing reduced MPO and cytokine levels at day 1.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This study screens epigenetic compounds to identify new latency reversing agents (LRAs) for reactivating latent HIV-1, finding two novel compounds with high reactivation efficiency and low toxicity.

The paper investigates how lipid droplets (LDs) sequester histones in Drosophila embryos, preventing their degradation and ensuring histone availability.

The paper reports the cryo-EM structure of the NALCN-FAM155A complex, revealing its sodium selectivity, voltage modulation, and disease-related mutation sites.

The paper identifies four dominant mutations, three significant multi-site co-mutations, and a 5'UTR CpG escape mutation that drive the rapid evolution of SARS-CoV-2.

This study shows that berberine treatment reduces adiposity and improves cardiac and pancreatic function in offspring exposed to gestational diabetes mellitus.

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

This study shows that suppressing IL-10 enhances T-cell antitumor activity and improves responses to checkpoint blockade in CLL.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

The paper investigates whether pre-existing cutaneous conditions increase SARS-CoV-2 infection risk by examining ACE2 expression and skin barrier function in human and mouse models.

This study identifies synergistic and antagonistic drug combinations against SARS-CoV-2 in vitro using in silico prioritization and experimental testing.

This study investigates how amino sugars like GlcN and GlcNAc affect gene expression and interactions between Streptococcus mutans and Streptococcus gordonii, revealing significant transcriptomic changes and metabolic reprogramming.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper identifies a small molecule that specifically binds to a tandem UU:GA mismatch motif in RNA, highlighting the importance of motif context for small molecule targeting.

This study shows that Th17 cells contribute to resistance to MEK inhibitor and anti-PD-L1 therapy in KRAS/p53 mutant lung cancers and suggests a triple combinatorial therapy to overcome resistance.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

This study shows that HDAC inhibitors butyrate and bufexamac inhibit de novo HIV-1 infection in CD4 T-cells without reactivating latent virus.

This study identifies isoplumbagin as a novel NQO1 substrate that exerts anti-cancer effects by modulating mitochondrial function and dynamics in multiple cancer cell lines.