L. Yang

This paper proposes an electrostatic-interaction-based mechanism for prion protein refolding from PrPC to PrPSc, identifying key steps involving hydrophobic interactions and pH changes.

This study identifies Notopterol as a JAK2/3 inhibitor that reduces inflammation and arthritis by blocking macrophage cytokine production in animal models.

This study shows that transient Dux overexpression improves SCNT and chemical reprogramming efficiency, while Dppa2/4 do not, and Dux treatment makes SCNT embryos resemble fertilized embryos.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

This study shows that NK cell inhibitory Ly49 receptors are essential for controlling MCMV infection in an MHC-restricted manner, supporting the missing-self hypothesis.

The paper crosses Pholiota adiposa and P. limonella to develop a high-yield hybrid strain for commercial cultivation.

The paper evaluates how advection and habitat loss interact to affect population persistence in riverine species, finding that restoring flow regimes can reduce persistence in degraded habitats if not paired with habitat protection.

This study shows mutant ACTB mRNA 3'UTR promotes HCC by interacting with miR-1 and miR-29a, leading to increased MET and MCL1 expression.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

The paper compares 3654 chloroplast genomes to uncover evolutionary patterns in green plants, identifying gene clusters and IR expansions.

The paper investigates how adaptive substitutions in Na+,K+-ATPase affect cardiac glycoside insensitivity in insects, revealing epistatic interactions that constrain evolution.

This paper shows that combining a MEK1/2 inhibitor with a TLR7 agonist enhances interferon responses in macrophages, improving survival in a melanoma model and identifying interferon genes as prognostic markers.

This study uses flow cytometry to assess dye uptake in E. coli knockout strains, revealing multiple transporters involved in dye accumulation and questioning their use as bioenergetic or DNA quantification tools.

This paper designs stimulus-responsive protein-based fractals using computational methods, achieving self-similar structures across multiple length scales.

This study shows miR-590-5p reduces radio-resistance in pancreatic cancer by inhibiting autophagy through targeting ATG3.

This study examines the evolution of cardenolide insensitivity in Orthoptera, finding predictable patterns similar to other insect orders and identifying sites under positive selection.

FabriEVEs is a database that collects, classifies, and annotates endogenous viral elements in non-mammalian species, enabling comparative analysis and host-virus co-evolution studies.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

This paper investigates the temperature-dependent duality of DHAP allelopathy in Picea schrenkiana, showing how its effects shift from promotion to inhibition with temperature changes, influencing forest succession.

This paper identifies metabolite pathways involved in oxidative stress responses of Aspergillus flavus over time, linking them to aflatoxin production and stress tolerance.

This study identifies stable reference genes for RT-qPCR normalization in Hypericum perforatum across tissues, developmental stages, and stress conditions.

This paper identifies a stable expression hot spot in Chinese hamster ovary cells using a lentivirus-based random integration method and validates its long-term expression stability.

This study shows sevoflurane increases mouse locomotion during anesthesia induction and briefly after recovery, with greater effects in Alzheimer's transgenic mice.

This study investigates the structure and function of the estrogen receptor alpha N-terminal domain using multiple techniques, revealing metastable contacts and their role in transactivation.

The paper describes a new standing rest behavior in Tibetan antelopes called 'Puppet behavior,' observed more frequently in males and linked to thermoregulation and anti-predation.

This study identifies circZKSCAN1 as a negative regulator of cancer stem cells in hepatocellular carcinoma, revealing its mechanism through interaction with FMRP and CCAR1-Wnt signaling.

This study shows TP, activated by Twist1, promotes HCC metastasis and VM via pentose Warburg effect by linking pentose phosphate pathway and glycolysis.