L. Zhang

The paper compares Muller's ratchet and Ohta's ratchet, finding that recombination may not significantly slow fitness decline in most parameter spaces.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.

This study shows that enhanced BCR signaling leads to early plasmablast and GC B cell death, affecting affinity maturation and B cell tolerance.

The paper shows that mIDH1 glioma stem cells secrete G-CSF, which reprograms myeloid cells to become non-immunosuppressive, altering the tumor microenvironment.

This paper shows hydroxychloroquine inhibits SARS-CoV-2 entry via cathepsin L but not TMPRSS2, and that combining it with a TMPRSS2 inhibitor enhances antiviral effects.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study shows ethanol metabolism in the CeA to acetate activates NMDAR, causing sympathoexcitation in rats.

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

This study identifies Aqp5 as a key factor in IPMN development using a novel mouse model, linking nuclear GSK-3β and oncogenic KRas to terminal duct cell expansion.

The paper investigates whether pre-existing cutaneous conditions increase SARS-CoV-2 infection risk by examining ACE2 expression and skin barrier function in human and mouse models.

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This study investigates the relationship between trimethoprim concentrations and antimicrobial resistance gene prevalence in river sites across the Thames catchment, finding significant seasonal and land-use correlations.

This study develops bent DNA bows to amplify and detect DNA interactions with salts and molecules, enabling sensitive and cost-effective analysis using gel electrophoresis and the modified Hill equation.

This study investigates the evolution, cross-species transmission, and origin of bat coronaviruses in China using sequence data and Bayesian analysis.

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This paper introduces two growth-based selections in E. coli to engineer CHMO with improved thermostability and NADH cofactor specificity.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

This paper describes the development of NTR 2.0, a modified nitroreductase with significantly improved efficacy for targeted cell ablation using metronidazole.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

The paper identifies two metabolic subclasses in pancreatic cancer cells and shows asparagine's role in supporting proliferation under mitochondrial stress, suggesting a new therapeutic strategy.

This study rapidly identifies a potent human monoclonal antibody against SARS-CoV-2 that neutralizes the virus in animal models and shows promise for therapeutic use.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.