L. Zhang

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

This study identifies the soluble guanylyl cyclase (sGC) pathway as a target for castration-resistant prostate cancer (CRPC) treatment, showing that riociguat inhibits CRPC growth and enhances radiation response.

Genomic data from 225 baboons reveal novel inter-species gene flow sites and local admixture effects across different lineages.

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

This study assesses genetic diversity in critically endangered Chieniodendron hainanense populations using GBS and SNP methods, finding limited diversity and weak genetic differentiation.

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

The study examines meiotic behavior in tea plant pollen mother cells, identifying normal and abnormal phenomena including cytomixis and other meiotic errors.

The paper shows that ANP treatment rescues preeclampsia symptoms in Axl knockout mice by improving trophoblast function through the AXL-CORIN-ANP pathway.

This study shows that clathrin light chains in Arabidopsis interact with autophagy proteins, impairing autophagy and leading to accelerated senescence and immune activation.

This study characterizes two bacterial O-methyltransferases, revealing their broad substrate scope and crystal structures, with implications for biocatalytic applications in drug development.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

This study shows that phosphorylation of Y57 in VAMP721 regulates SNARE function by modulating its activity and interaction with cognate partners.

This study examines blaCTX-M gene variants in E. coli from chicken and human sources in Ecuador, finding greater similarity between isolates from a rural community and suggesting potential gene transfer between chickens and humans.

This study uses spatial technologies to analyze high-grade gliomas, revealing distinct tumor niches and immune interactions linked to intra-tumoral heterogeneity.

This study shows that gasdermin D promotes influenza virus-induced mortality by amplifying neutrophil-driven inflammation.

This study identifies TIP1 as a key gene in Arabidopsis that regulates microbiota levels and composition, revealing two classes of autoimmunity: microbiota-dependent and microbiota-independent.

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.

This study identifies ERRs as regulators of autophagy through TFEB activation in cardiomyocytes, suggesting ERR targeting as a therapeutic strategy for heart failure.

Rolosense detects SARS-CoV-2 using a DNA-based motor that stalls in the presence of viral particles, offering a rapid, low-cost, point-of-care diagnostic method.

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

This study generates transgene-free canker-resistant citrus plants using Cas12a/crRNA RNP editing, achieving high mutation rates and regulatory approval.

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

This study compares multi-omics data across three plant sources of Amomi Fructus to identify genetic and transcriptomic differences, including gene flow and metabolic variation between populations.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

The paper improves 15N chemical shift prediction by incorporating conformational dynamics from MD simulations, showing better agreement with experimental NMR data at different temperatures.

This paper uses RNA sequencing to classify lung cancer subtypes and identifies drug repositioning opportunities based on lineage-specific responses.

The paper shows that phosphorylation and Lamin B receptor regulate PERIOD protein foci accumulation by modulating the circadian phosphatase MTS and kinase DBT.