L. Zhang

The paper identifies RNA methylation and autophagy-related genes in COPD using bulk and single-cell RNA sequencing data and validates them in animal models.

This study shows that MRTX1133, a KRAS G12D inhibitor, synergizes with 5-FU or ONC212 to reduce tumor cell viability and pERK in CRC and pancreatic cancer cells, regardless of KRAS mutation status.

This study shows that combining lurbinectedin with irinotecan and 5-FU significantly enhances the killing of pancreatic cancer cells.

The paper identifies a human HSC subset with inflammatory memory that accumulates with age and clonal hematopoiesis, potentially increasing cancer and infection risks.

This study identifies an atypical plant immune receptor, PML5, with a conserved deletion in its signaling domain that mediates cell death and immunity.

This study identifies eight neutrophil subtypes in COVID-19 using multi-omics data and finds that subtype C4 is associated with severe disease and may serve as a diagnostic biomarker.

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

This study shows losartan improves chemo-immunotherapy effectiveness in ovarian cancer by altering the tumor microenvironment and reducing IGF-1 signaling in cancer cells.

This study identifies dysregulation of γδ intraepithelial lymphocytes (IELs) before the onset of Crohn's disease-like ileitis in a mouse model.

This study shows vitamin D reduces ecDNA in hepatocellular carcinoma by stabilizing DNase1L3 via its transporter GC, leading to tumor suppression.

The paper links sulfur isotope fractionation to proteomic and metabolite profiles in Desulfovibrio vulgaris under different energy regimes, showing how energy flux affects protein abundance and isotopic composition.

The paper determines the crystal structure of phytoplasma effector SAP05 bound to plant Rpn10, revealing a ubiquitin-independent degradation mechanism and conserved interaction patterns across species.

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

This study demonstrates that IL-10-producing group 2 innate lymphoid cells (ILC210) can suppress Graft-versus-Host Disease (GVHD) in a humanized model without compromising graft-versus-leukemic effects.

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

The paper shows that nutrient levels affect root growth responses to high temperatures in plants, mediated by the HY5-NRT1.1 module across Arabidopsis, soybean, and rice.

libpspm provides a numerical library for solving physiologically structured population models with multiple methods and flexible model definitions.

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

This study reports the crystal structure and biochemical activity of the macro domain from rubella virus p150, showing it binds ADP-ribose and has mono-ADP-ribosylhydrolase activity.

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

This study uses MD simulations and free energy perturbation to analyze how spot mutations in SARS-CoV-2 RBD affect binding to ACE2, identifying which mutations strengthen or weaken the interaction.

This study identifies MIZ1-TMBIM4 as a mechanism safeguarding IgG1+ GC B cell positive selection by regulating Ca2+ mobilization and preventing mitochondrial dysfunction.

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

This study examines the effects of intramammary ceftiofur treatment on dairy cattle gut microbiome and antibiotic resistance, finding persistent changes in microbiome abundance and resistance gene abundance up to 9 weeks post-treatment.

This study identifies a non-covalent interaction between Ebola virus VP35 and ubiquitin chains that supports viral replication and discovers compounds that block this interaction to reduce viral activity.

This study shows MKP1 suppresses AMPK activity via LKB1 nuclear retention, promoting NASH by inducing hepatocyte death and inflammation.

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

This study identifies Nsp1's role in enhancing SARS-CoV-2 translation by interacting with EIF1A, leading to reduced viral titers when EIF1A is depleted.

The paper introduces ELAP-seq, a method to detect pseudouridine modifications in RNA with high sensitivity and resolution, identifying over 10,000 sites in human transcripts.