L. Zhang

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

This study examines the gut microbiome and antimicrobial resistance gene dynamics before and after enteric infection, finding higher resistance gene diversity during infection and shifts in microbial composition post-recovery.

This study uses phylogenomic analysis of macaque genomes to show that incomplete lineage sorting and ancient hybridization contributed to the radiation of macaques.

This study shows that acetoacetate activates human neutrophils via FFA2R, affecting cAMP levels, calcium signaling, ROS production, and migration.

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

This paper develops cholesterol-deficient T cell membrane-coated nanoparticles to deliver STING agonists for tumor immunotherapy, showing improved blood clearance evasion and enhanced antitumor effects.

This paper investigates the role of MoCK2 in rice blast fungus metabolism and mitochondrial protein import, finding it affects acetyl-CoA production and mitochondrial function essential for pathogenesis.

Disruption of glucosinolate catabolic genes, BGLU28 and BGLU30, in sulfur-starved mature Arabidopsis impaired growth, affected glucosinolate distribution, and altered transcriptional profiles.

This study shows that Leptospermum extract (QV0) reduces pleural mesothelioma tumour growth in vitro and in vivo by inducing mitochondrial dysfunction and apoptosis without adverse effects.

The paper analyzes gene age and subcellular expression patterns in Drosophila species using PacBio sequencing, finding new genes enriched in extracellular compartments and old genes in mitochondria and plasma membrane.

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

This study identifies a direct interaction between NF2 and TEAD4, showing NF2 inhibits TEAD4 stability and function, revealing a new mechanism of NF2's tumor suppressor role via the Hippo pathway.

This paper introduces HITAG, a method for high-throughput tagging of endogenous loci to study protein function, and demonstrates its use in analyzing stress granule-associated proteins.

Root Walker quantifies root growth responses to environmental signals using automated imaging and analysis, revealing auxin concentration dependence and MAPK inhibitor specificity.

The paper characterizes phenotypic, genomic, and transcriptomic heterogeneity in MIA PaCa-2 pancreatic cancer cell clones, showing distinct traits and suggesting its use as a model for studying cancer heterogeneity.

The paper examines how tidal fluctuations and human disturbances affect microbiota structure and assembly in intertidal groundwater-surface water systems, identifying rhythmic microbial patterns and their environmental drivers.

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

The paper shows that ubiquitination of SRF3 organizes its plasma membrane nano-organization, directing signaling outputs based on environmental cues like low iron or bacterial signals.

The paper identifies Zn2+ as a therapeutic agent for calcium oxalate kidney stones by enhancing oxalate-degrading bacteria and their enzymes in the gut microbiota.

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

The paper shows that mucins from the laminated layer of E. granulosus are captured by Kupffer cells via Clec4F, highlighting a mechanism for host clearance of parasite-derived materials.

A synthetic ERRα agonist activates an acute aerobic exercise genetic program in skeletal muscle, enhancing exercise capacity and mitochondrial function in mice.

This study shows that KMT2D regulates thymic egress by affecting maturation and integrin expression in T cells, leading to immune dysfunction in Kabuki syndrome type 1.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study engineers a plant enzyme to increase the production of methylated flavonoids in engineered microbes.

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This study identifies GPR183 as a key receptor guiding CD301b+ cDC2 to a TSLP-dependent survival niche in the lung adventitial cuff.