P. Zhang

This study uses cryo-imaging to reveal SARS-CoV-2 replication, assembly, and egress pathways in infected cells.

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

The paper develops an LC-MS-based untargeted metabolomics protocol to analyze micro-scale extracellular metabolites from hepatocytes and identifies metabolite shifts over time.

This study reevaluates Spinach-based RNA visualization in plants, showing potential for ex vivo and in vivo RNA monitoring.

The paper investigates fungal and yeast communities in spontaneous wine fermentations, finding geographic differentiation and S. cerevisiae's role in shaping wine aroma profiles.

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

The paper investigates belowground plant-plant communication triggered by root nematode infection, finding that nematode-free roots emit signals leading to compensatory growth in neighboring plants.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

The paper compares decidual vasculopathy in central and peripheral placental regions, finding more vasculopathy in the periphery but more regeneration in the center, with no effect of preeclampsia.

This study identifies hypoxia-targeted mRNAs in cancer exosomes that promote angiogenesis and reprogram recipient cells.

The paper visualizes a novel single-shelled icosahedral intermediate of mammalian orthoreovirus using cryo-electron tomography, revealing structural insights into viral assembly.

The paper develops a comparative modeling approach to study CDK9 inhibitor selectivity and structure-activity relationships, using existing PDB data and validating with a crystal structure.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

The paper uses serial cryoFIB/SEM to show cytoarchitectural disruptions in Leigh syndrome patient fibroblasts due to a USMG5 mutation.

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

The paper examines WT1 expression in endometrium across different physiological and pathological conditions, linking it to progesterone effects and gestational vascular changes.

The paper presents a workflow for microED that enables routine atomic structure determination of protein crystals of any size and shape, demonstrated with proteinase K to 2.0 Å resolution.

This study identifies MeSSII's role in cassava starch biosynthesis by forming protein complexes with other enzymes, affecting amylose and amylopectin synthesis.

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

This study investigates the transcriptomic response of Caenorhabditis elegans to acidic stress environments, identifying two major pathways involved in cuticle synthesis and xenobiotic metabolism.

The paper identifies the composition and characteristics of lipid droplets in bovine luteal tissue, showing they store cholesteryl esters and triglycerides, and differ from other bovine tissues.

This study shows that reducing rRNA gene copies in Arabidopsis leads to genomic instability, chromosomal duplications, and altered gene expression, including enhanced resistance to pathogens.

This study shows that Bacillus subtilis spore enhances mucosal immunity by promoting intestinal-resident memory T cells through ICAM-1 expression on dendritic cells.

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

This paper characterizes the kinetics of the radical-mediated C-C bond formation in MoaA, revealing a shunt pathway and determining the rate of the 3',8-cyclization step.