P. Zhou

This study identifies CDH2 as a driver of niche-mediated treatment resistance in leukemia and shows that ADH-1 can effectively target this resistance in preclinical models.

The paper identifies a novel lineage of SARS-related coronaviruses from bats that use bat ACE2 receptor but not human ACE2, suggesting potential zoonotic risks.

This study identifies a p53-like transcription activation domain in PIF3 and shows that PHYB binding inhibits its activity, revealing a photoresponsive transcriptional switch in Arabidopsis.

This study tracks the genomic evolution of ST11-CRKP during antibiotic therapy in a patient, identifying mutations linked to reduced virulence and increased host adaptation.

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.

This study identifies a broadly neutralizing antibody that targets a conserved site on beta-coronavirus spike proteins and provides protection against SARS-CoV-2 infection.

The paper assesses chromatin accessibility and DNA methylation in four structurally diverse maize genomes, revealing conservation of features with dynamic boundaries in unmethylated regions.

This study identifies chloroplast ribosomal protein expression heterosis as a quantitative predictor of plant height heterosis in maize hybrids.

This paper shows that anakinra, an IL-1 receptor antagonist, reduces fat browning and muscle wasting in Ctns-/- mice, suggesting it could treat cachexia in infantile nephropathic cystinosis.

This study shows that blocking IL-1 receptor reduces adipose browning and muscle wasting in CKD-associated cachexia in mice.

The paper uses transcriptome profiling of maize under heat and cold stress to identify cis-regulatory elements and develop models predicting gene expression responses.

The paper develops a method to trace the geographic origin of quarantine insects using their gut microbiota, finding that microbiota diversity and composition correlate with geographic and environmental factors.

This study identifies divergent immune resistance mechanisms in melanoma and basal cell carcinoma that explain differential responses to checkpoint immunotherapy.

The paper identifies TE insertions that influence gene expression in maize by disrupting or carrying accessible chromatin regions, showing TEs can create novel regulatory elements.

This study identifies bosutinib as a radiosensitizer for breast cancer by targeting eIF4G1, enhancing radiation efficacy and reducing drug dosage.

This paper develops a multiplexed CRISPR/Cas9 system with Trex2 exonuclease to improve genome editing efficiency in Setaria viridis, achieving high mutation rates and MMEJ-mediated repair.

The paper identifies widespread maternal expression of genes and transposable elements in maize endosperm using whole genome assemblies from reciprocal crosses, revealing imprinted expression patterns and fused transcripts.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This study shows that ATP released by Candida albicans activates non-peptidergic neurons to enhance anti-Candida immune responses.

This study investigates the intestinal absorption of morroniside using a Caco-2 cell model, finding pH- and temperature-dependent transport and involvement of efflux proteins.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

The paper investigates phylogenetic relationships among Avena taxa using the Pgk1 gene, revealing structural divergence and evolutionary relationships between genomes.

This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.

This study shows that thermoneutrality causes skeletal muscle myopathy through brown adipose tissue via IRF4 and myostatin mechanisms.

The paper analyzes the evolution and adaptation of H7N9 influenza viruses in China, identifying lineage-specific mutations and high-pathogenicity strains.