Q. Li

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

This study identifies neo-functionalization and co-option of Pif genes in oysters that contribute to the evolution of a novel shell microstructure called chalky calcite.

This paper establishes a hairy root culture and genetic transformation system in Stephania tetrandra to enhance bisbenzylisoquinoline alkaloid production.

The paper shows doxorubicin inhibits MoPSD2, a phosphatidylserine decarboxylase in Magnaporthe oryzae, reducing fungal growth and crop disease severity.

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

The paper shows that Plasmodium falciparum adjusts its tRNA profile and codon usage to adapt to amino acid availability from hemoglobin digestion, affecting protein synthesis and proliferation.

This study shows that S. aureus CRISPR-Cas systems, located within SCCmec cassettes, limit phage proliferation but are inefficient, with phages able to escape or overload the system.

The paper develops a short gradient, multi-CV FAIMSpro BoxCarDIA workflow for quantitative proteomic time-course analysis in Arabidopsis thaliana under osmotic and salt stress, quantifying over 9700 unique protein groups.

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

This study shows Sox4 initiates hepatobiliary metaplasia by first closing hepatocyte enhancers and then opening biliary enhancers in adult liver cells.

This study tests mucoactive drugs that enhance mucociliary clearance and finds three inhibit SARS-CoV-2 replication in human airway epithelial cells by improving ciliary function and redox state.

The paper shows quorum sensing represses the Type III-A CRISPR-Cas system in S. aureus by inhibiting SarA and ArcR, which are positive regulators of the system.

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

This study determines the structures of human ABCC4 in apo and complexed forms, revealing its role in exporting platelet agonists and inhibitors, and identifying a pocket for drug design.

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

This study shows that shrimp STING detects DNA to trigger an interferon-like antiviral response, independent of cGAS and involving the IRF-Vago pathway.

This study uses computational models to show that weak-rectified gap junction coupling and electrically isolated distribution of bio-pacemaker cells enhance their pacing efficiency.

This study identifies two groups of metabolites in lamprey buccal glands that modulate host responses and establishes a spatial metabolomics database for lamprey research.

This study identifies distinct molecular mechanisms for proactive and retroactive interference in Drosophila during consecutive learning tasks.

This study describes a new saurosphargid species from the Early Triassic of South China and presents a phylogenetic analysis clarifying the relationships of sauropterygians and their evolutionary history.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

The paper examines how tinamou egg coloration relates to mating signals and eco-geographical distribution, finding associations with song variables and differences in similar habitats.

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

This study examines the effects of Salton Sea playa dust on pulmonary inflammation in mice, finding acute neutrophil inflammation similar to innate immune responses.

This study develops molecular markers for KTI mutant alleles in soybean using CRISPR/Cas9 to aid in breeding low TI trait cultivars.

This study shows that p53 restoration in SCLC can induce necrosis via cyclophilin-dependent mechanisms, revealing subtype-specific responses and potential therapeutic targets.

The paper identifies and analyzes non-spicular demosponge fossils from the lowermost Triassic in Armenia, proposing criteria for their recognition and discussing their evolutionary significance.