Q. Li

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

The paper investigates how cholesterol in a cargo membrane affects kinesin-1 binding to microtubules in the presence of tau, showing that cholesterol enhances tau's inhibitory effect.

The paper shows that trophic strategies of small eukaryotic phytoplankton explain their ocean niches based on tradeoffs between phototrophy and phagotrophy.

This study investigates DNA methylation inheritance in Pacific oysters, finding that half of parental methylation differences are passed to offspring and revealing sex-specific methylation patterns linked to Rho signaling.

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

This study combines CODEX and RNAscope to enable simultaneous detection of proteins and RNA on single tissue sections and assesses cross-reactivity of CODEX antibodies in rhesus macaques.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

Proteomics identified differences in wheat resistance to Pst and Bgt, with TaGSTU6/TaCBSX3 interaction specifically enhancing resistance to Bgt.

This study shows that TLR9 mediates SLFN+-MDSC polarization during Helicobacter-induced gastric metaplasia, with the TLR9 C allele linked to increased risk of neoplastic complications.

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

This study investigates MCT deficiency in Syrian hamsters infected with SARS-CoV-2, finding a 67% reduction in MCT rate by 2 dpi due to decreased motile ciliation.

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

This paper develops an engineered A549 cell model overexpressing ACE2 and TMPRSS2 to study SARS-CoV-2 infection and antiviral responses.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study examines the long-term effects of soy lecithin exposure on gut microbiota from individuals with high and low emulsifier sensitivity using the M-SHIME model.

This study compares the effects of rhamnolipids and TWEEN80 on gut microbiota composition and function in the SHIME system, showing opposite impacts and highlighting donor-dependent responses.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This study shows that Igf1 deletion in TMJ fibrocartilage stem cells causes cartilage degeneration and worsens osteoarthritis in mice.

The paper uses long-read sequencing to identify novel transcripts and isoform changes in primate transcriptomes, highlighting immune-related regulatory divergence.

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

This study investigates how recurrent UTI and estrogen influence the urobiome's taxonomic and functional features in postmenopausal women using metagenomic and metabolomic analyses.

This study investigates how ACE2 and antibodies affect the conformational dynamics of the SARS-CoV-2 spike protein using smFRET and FCS, revealing that D614G modulates RBD energetics similar to ACE2 binding.

This study uses multi-omics analysis to show that RVE8-like proteins in Arabidopsis affect carbohydrate metabolism and proteasome activity, leading to altered plant growth and physiology.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.