Q. Zhou

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study identifies UGP2 as essential for pancreatic cancer growth by regulating glycogen and N-glycosylation, with potential therapeutic implications.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

The paper identifies the avian W chromosome as a reservoir for active endogenous retroviruses, potentially contributing to female-biased mutational load and genetic incompatibilities.

The paper identifies new integrin antibodies that inhibit fibrosis progression in lung injury models and show superior in vitro activity in fibroblasts.

This study shows CTGF contributes to TGF-β1-induced lung fibrosis in a rat model and patients with IPF, and that pamrevlumab can partially reduce fibrosis.

The paper investigates the evolution of a sex megachromosome in cichlid fish, finding it consists of three distinct regions and contains unique genomic features.

This paper develops a synthetic DNA-based vaccine platform to rapidly generate SARS-CoV-2 vaccines using recombinant MVA vectors expressing spike and nucleocapsid antigens, showing robust immune responses in mice.

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

The study identifies two thermal ecotypes within a nearly genetically identical Synechococcus population, showing functional diversity in temperature adaptation.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

The paper presents a high-resolution cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing new structural features and interactions.

This study shows that increasing stiffness of MC-GAG scaffolds enhances osteogenesis through YAP/TAZ and Wnt signaling, while BMPR signaling is independent of mechanical cues.

This study presents the structures of human KCC2 and KCC3, including phosphorylation and inhibitor-bound forms, revealing mechanisms of regulation and potential drug targets.

This study determines the cryo-EM structure of human ACE2 bound to the RBD of 2019-nCoV, revealing key interactions and differences compared to SARS-CoV.

The paper presents the cryo-EM structure of human ACE2 in complex with B0AT1, revealing dimeric conformations and potential binding sites for SARS-CoV spike proteins.

This study isolates lymphovascular breast cancer cells using LCM and G&T-seq to identify three distinct clonal pathways associated with different survival outcomes and ribosomal protein downregulation as a poor prognosis marker.

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

This study estimates the economic burden of severe mental disorder in China from 2014-2017 using prevalence-based methods, finding substantial direct and indirect costs.

This study investigates how temperature and light affect the survival of Plasmodiophora brassicae resting spores in soil, finding that lower temperatures and burial improve survival while UV light reduces viability.

This study investigates sex chromosome evolution in paleognath birds, finding that tinamous have higher substitution rates and unique evolutionary strata without chromosomal inversion.

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

This study identifies widespread arginine phosphorylation in human cells using a novel phosphoproteomic workflow, revealing 152 high-confidence sites across 118 proteins.

The paper reports cryo-EM structures of RyR2 bound to modulators, revealing how Ca2+ and other molecules regulate channel gating and provide insights into cardiac disorder mechanisms.

The paper identifies 14 genes transposed from Z to W chromosomes in songbirds within 9 million years, showing that sex-specific and dosage selections help restore genes on degenerating W chromosomes.

This study shows TAZ uses phase separation to compartmentalize transcription factors and enhance gene expression, distinct from its paralog YAP.

This study infers tumor cell-specific transcription factor binding from cell-free DNA to predict tumor subtypes and detect cancer early.