Q. Zhou

This study shows that engineering human stem cell-derived islets to secrete tolerogenic cytokines can prevent xeno-rejection without immunosuppression or encapsulation.

This study identifies DNALI1 as a key protein in sperm development, showing its role in the MEIG1/PACRG complex for cargo transport along the manchette and its involvement in sperm individualization.

The paper screens hydrocarbon-stapled peptides targeting the SNARE-Syt1 primary interface to inhibit Ca2+-triggered exocytosis and mucus hypersecretion.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

This paper shows that the synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates through various vaccination routes and dose regimens.

This study shows how matrix viscoelasticity influences tissue organization by causing symmetry breaking and branching in epithelial cell aggregates.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

This study identifies ADAR2 downregulation in t(8;21) AML and shows its role in suppressing leukemogenesis through RNA editing.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

The paper analyzes single-cell transcriptome data to show that new genes in Drosophila testis show expression shifts and chromosomal distribution patterns consistent with meiotic sex chromosome inactivation.

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

The paper identifies three new folds in the solute carrier superfamily, with one validated experimentally in the SLC44 family, providing insights into structure-function relationships.

This study shows that beta-catenin limits osteogenesis on stiff nanoparticulate mineralized collagen glycosaminoglycan scaffolds by modulating Wnt and mechanotransduction pathways.

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study demonstrates that AvFc, a lectibody targeting high-mannose glycans, inhibits cancer cell migration and tumor growth in mice by blocking EGFR and IGF1R activation.

This study shows TTC36 protects renal tubular cells from cisplatin-induced apoptosis by maintaining mitochondrial homeostasis and autophagy.

This study develops a dual-modality system to investigate high-frequency ultrasound's effect on neuronal activity in awake mice, achieving 100-micron spatial resolution.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study identifies and characterizes two CoAT enzymes from bacteria, showing CPB6-CoAT can catalyze both butyrate and caproate synthesis, while BEY8-CoAT only catalyzes butyrate synthesis.

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

This study shows that MiaA, but not MiaB, is critical for the fitness and virulence of ExPEC, and that stress can alter MiaA expression to affect translation and proteome composition.

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

This paper uses infrared spectroscopy to analyze the temperature-dependent hydrogen bonding between SARS-CoV-2 RBD and antibodies, finding increased binding strength at higher temperatures.

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

This study shows that noninvasive transcranial ultrasound increases brain uptake of intrathecally delivered drugs and antibodies by enhancing glymphatic fluid transport in rats.