S. Bhattacharya

This study shows that alpha-ketoglutarate inhibits Akt-driven thrombosis and inflammation by enhancing PHD2 activity and reducing pAkt1 levels in platelets and leukocytes.

This study shows that biomechanical properties of the limbal niche regulate YAP activity, which is essential for maintaining stemness and regeneration in corneal epithelial stem cells.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

This study identifies residue networks mediating allosteric communication from the Ang II binding site to Gq and β-arrestin2 coupling sites in AT1R, revealing shared and distinct residues that could guide biased ligand design.

This study evaluates the redox buffering capacity of nanomaterials to assess their therapeutic potential and toxicity in a preclinical animal model.

This study uses electron microscopy to analyze ultra-structural changes during encystation in Entamoeba invadens, identifying early nuclear modifications and structural transformations.

The paper develops a synthetic gene promoter repressed by flavonoids to create an intracellular sensor for molecular events.

The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.

The paper shows that mitochondrial Ca2+ uniporter (MCU) expression in alveolar type 2 cells determines ARDS severity by affecting Ca2+ buffering capacity.

The paper examines how sedimentation rates and organic matter dynamics influence microbiome structure and function in different oxygen minimum zones along the Arabian Sea margin.

This study shows site-specific S-palmitoylation of IFITM3 enhances its membrane interactions and antiviral activity by modulating its conformation and lipid membrane binding.

The paper shows how cell shape changes affect subcellular organelle positioning, altering Ca2+ signaling and phenotypic function in vascular smooth muscle cells.

This study shows Asterix/Gtsf1 binds tRNAs and is essential for piRNA-mediated silencing of LTR retrotransposons.

The paper shows NBS1-CtIP-mediated DNA end resection prevents cGAS from binding to micronuclei by modifying chromatin architecture.

This study identifies two distinct limbal stem cell populations with different proliferation rates and regulatory mechanisms in mice.

This study identifies SETD2 as a factor that interacts with hnRNP L to regulate alternative splicing by linking transcription and splicing through its SHI domain.

This study shows that the disordered N-terminal region of SETD2 regulates its proteasome-mediated decay, affecting H3K36me3 deposition and transcriptional fidelity.

This study shows that the pyruvate dehydrogenase complex (PDC) is salt-labile and structurally variable, with activity affected by ionic strength.

The paper shows that DNA methylation reduces H3.3 levels in HCC, affecting transcription and cell proliferation, and suggests DNMT and HDAC inhibitors as potential therapies.

This study identifies the N-terminal region of SETD2 as critical for its proteasomal degradation and shows that its removal increases H3K36me3 levels independently of Pol II.

This study shows that intermittent chemotherapy can suppress chemoresistance in lung cancer by preventing the emergence of tolerant cells through dynamic phenotypic switching.

This study identifies miR-30e as a master regulator of innate immune responses during HBV infection and SLE, showing its role in modulating immune pathways and therapeutic potential.

This study compares glucosinolate allocation in fruits of two Lepidium species with different dispersal strategies and dormancy status, finding differences in concentration and class distribution between immature and mature tissues.

This study develops a 3D in vitro model (3D-O) that mimics physiological oxygen levels in breast cancer, showing hypoxia-induced changes that promote immune evasion and reduced CD8+ T cell infiltration.

This study shows collagen I weakly interacts with β2-microglobulin, promoting conformational exchange that leads to amyloid formation.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

The paper identifies metabolically-active obligate aerobes in anoxic marine sediments by combining culture-dependent and -independent methods, revealing their survival through cryptic oxygen production.

This study identifies the molecular mechanism of thiosulfate oxidation in Pusillimonas ginsengisoli, revealing a unique pathway involving tetrathionate and glutathione.

The paper investigates the role of tetrathionate in the sulfur cycle of Arabian Sea OMZ sediments, revealing its microbial and geochemical sources and transformations.

This paper identifies two distinct pathways for thiosulfate oxidation in Paracoccus thiocyanatus SST: a Sox system and a Tetrathionate-Intermediate pathway, with the latter being more efficient for thiosulfate conversion.