S. Das

This study develops DeltaMAX, an affinity-matured DLL4 ligand that broadly activates or inhibits Notch signaling in human and murine systems.

The paper shows that PSMA-bearing extracellular vesicles from prostate cancer cells promote a pro-angiogenic tumor microenvironment by increasing VEGF-A, angiogenin, and 4EBP-1 phosphorylation.

This paper identifies picolinic acid as a broad-spectrum antiviral that inhibits enveloped virus entry, showing efficacy against SARS-CoV-2 and Influenza A Virus in animal models.

The paper presents a strategy using cGMP analogues to selectively modulate rod or cone photoreceptor function in retinal degeneration, preserving normal CNG-channel function.

This study uses immunoinformatics and molecular dynamics to design a polyvalent epitope-based vaccine against RSV-A and RSV-B, selecting conserved epitopes and validating structural stability.

The paper uses AI to identify a racially influenced immune driver of esophageal and gastroesophageal junction adenocarcinomas, showing its absence in African Americans and association with neutrophil processes and genetic variants.

This paper introduces a rapid method for counting bacterial colony-forming units using micro-colony observation, achieving results comparable to traditional dilution plating with reduced time and labor.

This paper develops a deep learning model to estimate GBM tumour parameters and predict progression using MRI data.

This study evaluates the combined solar photo-Fenton and bacterial degradation of chlorpyrifos in wastewater and assesses its toxicity to zebrafish.

This study shows that transient hydrophobic interactions drive lateral clustering of cadherin-23 on membranes, enhancing cell adhesion without requiring specific cis-dimer interactions.

The paper assesses the impact of RG203KR mutation in SARS-CoV-2 nucleocapsid using virus-like particles, showing enhanced immune responses and neutralization.

This study shows that antibiotic treatment of Salmonella Typhi can generate L-form bacteria that infect macrophages and mice, suggesting a mechanism for antibiotic resistance and disease transmission.

The paper examines how different growth forms of bamboo affect mycorrhizal fungi and fluorescent pseudomonas populations in their rhizosphere.

This paper develops a novel CAR T-cell scaffold with immune-evasive properties to enable universal allogeneic CAR T-cell therapy.

This study presents a computational framework to analyze neutralizing antibody specificities in response to dengue vaccines, revealing differences in immune responses based on prior infection status.

This study identifies shared cellular and molecular features between severe COVID-19 and idiopathic pulmonary fibrosis, highlighting ER stress and AT2 cell dysfunction as key drivers.

The paper shows that inducing tubular lysosomes through dietary restriction or mTOR inhibition links reduced food intake to lifespan extension in C. elegans.

This study shows that egg size and hatching time evolve in response to different larval crowding regimes in Drosophila, with egg size consistently correlating with increased competitive ability.

The paper identifies distinct extracellular tRNA-derived small RNA (tDR) fragmentation signatures associated with different stress responses and shows their potential as biomarkers in human disease.

The study examines how exposure and food categorization influence extraction methods in urban macaques when dealing with processed food.

This study investigates miR-181c's role in diet-induced obesity by showing its regulation of lipid synthesis in liver and its impact on metabolic parameters.

This study evaluates the regeneration capacity of size-dependent micro-tissue scaffolds derived from Capra ear cartilage for cartilage defect treatment in rabbits.

This paper shows that GIV/Girdin modulates DNA damage response by suppressing HR and promoting NHEJ through BRCA1 sequestration and Akt pathway activation.

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

This study shows that zinc ions inhibit SARS-CoV-2 main protease and viral replication in vitro, with structural evidence supporting the mechanism.

The paper demonstrates a genetically engineered insect system using sex-selection and genetic incompatibility for population suppression in Drosophila melanogaster.

The paper investigates how WxxxE bacterial effectors interact with ELMO1 to regulate inflammation, showing that ELMO1 differentiates pathogenic from commensal bacteria and enhances inflammatory responses through these interactions.

This study identifies lung epithelial signaling as critical for early vaccine-induced CD4+ T cell activation and Mtb control in BCG vaccinated hosts.

The paper identifies LMO2-expressing tumor cells as metastasis-initiating cells and shows LMO2-STAT3 signaling promotes breast cancer metastasis.

This study shows that genetic inhibition of SGK1 reduces obesity-related atrial fibrillation in mice by decreasing fibrosis, inflammation, and altering electrophysiology.