S. Das

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

UVC-based air disinfection system for rapid inactivation of SARS-CoV-2 present in the air

This study demonstrates that UVC-based air disinfection systems can rapidly inactivate SARS-CoV-2 in aerosols by damaging its nucleic acids and altering its Spike protein conformation.

A novel role of macrophage PIST protein in regulating Leishmania major infection

This study shows that macrophage PIST protein regulates Leishmania major infection by interacting with Beclin 1 and affecting parasite replication.

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy.

This study develops FAP-targeted CAR-T cells to deplete stromal CAFs, enhancing tumor infiltration and anti-tumor activity in solid tumors.

Seasonal plasticity and energy efficiency in migratory buntings is an assemblage of alterations in metabolic and gut microbe adaptations.

This study identifies state-specific changes in serum metabolites and gut microbiota of migratory buntings during different life stages, highlighting metabolic and microbial adaptations during migration.

Probing the ligand binding specificity of FNBP4 WW domains and interaction with FH1 domain of FMN1

This study investigates the binding specificity of FNBP4 WW domains with the FH1 domain of FMN1 using surface plasmon resonance and ELISA, revealing that only the first WW domain is involved in the interaction.

Toxic metal uptake by oyster mushrooms grown in sugarcane bagasse

This study investigates metal uptake by oyster mushrooms grown on sugarcane bagasse, finding biomagnification of heavy metals in mushrooms compared to the substrate.

Effect of Lantana camara ethanolic leaf extract on survival and migration of MDA-MB-231 triple negative breast cancer cell line

This study shows that Lantana camara leaf extract inhibits MDA-MB-231 breast cancer cell survival and migration through apoptosis and cell cycle arrest.

A single dietary factor, daily consumption of a fermented beverage, can modulate the gut microbiome within the same ethnic community

This study examines how daily consumption of a fermented beverage affects the gut microbiome and health of a specific ethnic community in India.

Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions

This study identifies molecular sub-types of canine soft tissue sarcomas through multi-omics analysis, revealing recurrent mutations and fusion events that may inform diagnosis and therapy.

Evolution of mate harm resistance in females from Drosophila melanogaster populations selected for faster development and early reproduction

This study shows that female mate harm resistance decreases in Drosophila melanogaster populations selected for faster development and early reproduction, likely due to changes in breeding ecology and male trait evolution.

Deep divergence and genomic diversification of gut symbionts of neotropical stingless bees

The paper analyzes the gut microbiota of neotropical stingless bees, finding genomic divergence and evidence of host switches in their microbial evolution.

Selective degradation of ARF monomers controls auxin response in Marchantia

This study quantitatively maps the auxin signaling pathway in Marchantia by analyzing NAP protein dynamics and identifies ARF degradation as a regulatory mechanism for auxin response.

Synonymous and non-synonymous transitions/transversions vividly disclose purifying selection in Escherichia coli coding sequences

The paper develops a method to estimate the ti/tv ratio in E. coli coding sequences by accounting for codon degeneracy and pretermination codons, revealing insights into purifying selection.

Copper-independent lysosomal localization of the Wilson disease protein ATP7B

This study reveals that ATP7B, the Wilson disease protein, has a copper-independent lysosomal localization in hepatocytes and recycles between TGN and TGN-proximal lysosomes for copper transport.

Targeted Vibration-Induced Necrosis in Cancer Cells using Paramagnetic Microrobots

This study uses magnetic microrobots to target and destroy cancer cells through localized magnetic oscillations.

A mechanistic insight into Nigella sativa mediated anticancer effect on breast cancer through regulation of various miRNAs: An in vitro & in vivo study

This study investigates the anticancer effects of Nigella sativa volatile oil on breast cancer cells and mice, showing synergistic anti-tumorigenic properties through miRNA regulation and apoptosis induction.

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

This paper develops PADLE, a phage-assisted method to evolve potent HDAC8 inhibitors, identifying two highly selective and potent inhibitors with sub-nanomolar Ki values.

Revisiting the burden borne by fumarase: enzymatic hydration of an olefin

This study investigates the catalytic mechanism of class-I fumarate hydratase by analyzing structural and computational data from Methanocaldococcus jannaschii and Leishmania major enzymes.

Activation of ERK by altered RNA splicing in cancer

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

Hepatitis C virus non-structural proteins modulate cellular kinases for increased cytoplasmic abundance of host factor HuR and facilitate viral replication

This study identifies how HCV proteins NS3 and NS5A modulate host kinases to increase cytoplasmic HuR levels, enhancing viral replication.

The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses

This study shows that ELMO1 and NOD2 interact to control intestinal inflammation and bacterial clearance, with their dysfunction linked to Crohn's disease.

Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

Glioma-BioDP: Database for Visualization of Molecular Profiles to Improve Prognosis of Brain Cancer

Glioma-BioDP provides a web tool for exploring RNA and protein expression profiles in low- and high-grade gliomas to aid in prognosis and treatment personalization.

Spatially Resolved Metabolites in Stable and Vulnerable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

The "LINC" in between Delta40p53-miRNA axis in the regulation of cellular homeostasis

This study investigates how Delta40p53 regulates the LINC00176-microRNA-mRNA axis, affecting cellular processes and homeostasis independently of full-length p53.

Green emitting carbon quantum dots (GCQDs) to probe endocytic pathways in cells; for tissue and in vivo bioimaging

This study synthesizes green emitting carbon quantum dots (GCQDs) for in vitro and in vivo bioimaging, showing their uptake via clathrin-mediated pathways in mouse cells and zebrafish embryos.

CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancers

This study identifies TOLLIP as a critical adaptor for CK2 signaling from perinuclear endosomes in KRAS and NRAS mutant cancers, showing its role in tumor proliferation and progression.

Engineering Proprioceptive Implants via Surgical and Regenerative Approaches: Preliminary Interpretations

This paper demonstrates a method to engineer proprioceptive dental implants using biodegradable scaffolds and stem cells in rabbits, aiming to restore proprioception in implants.

Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2

This study identifies an evolutionarily conserved 'E-L-L' motif in the SARS-CoV-2 spike protein as a target for small molecule fusion inhibitors, showing posaconazole effectively blocks viral entry across variants.