S. Huang

This paper characterizes a glycolipid glycosyltransferase (GTcp) from Candidatus Pelagibacter sp. HTCC7211, showing its broad substrate specificity and role in glycoglycerolipid synthesis under phosphorus stress.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

This study determines the cryo-EM structure of the 5-HT1F receptor complex with lasmiditan and a G protein, revealing the mechanism of selective activation and informing drug design.

The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.

This study identifies heat-responsive genes in pea anthers and stipules using RNA sequencing and qPCR, revealing shared and variety-specific gene expression changes related to heat tolerance.

This paper isolates and characterizes a quinclorac-degrading bacterium, Cellulosimicrobium cellulans sp., showing 45.9% degradation efficiency and identifying two novel degradation products.

The paper identifies a distinct population of red cells in lung tissues, called Red Soma Cells (RSC), which contribute to lung redness and have unique biological functions.

This study finds that synovial levels of IL-8, MIP-1α, and VEGFA correlate with lubricin glycan truncation in OA, suggesting a link between glycan changes and local inflammation.

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

This study identifies and characterizes six AcMNPV-encoded miRNAs, showing they regulate both viral and host genes through suppression or enhancement of target expression.

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

The paper identifies flavinylation's role in diverse extracytosolic redox functions across bacteria through genomic analysis and gene cluster mining.

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

The paper introduces IRCA to infer metabolite conversion networks from single-cell Raman spectra of isogenic populations without time-series data.

This study uses MSOT to non-invasively visualize lipid accumulation in mice with NAFLD, showing its potential for monitoring hepatic steatosis without contrast agents.

This study uses sedimentary ancient DNA to analyze plant diversity changes over 28,000 years in Far East Russia, revealing different assembly rules in cold and warm climates.

This study shows natural transformation in Staphylococcus aureus facilitates SCCmec transfer, contributing to MRSA emergence.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

This study uses immune simulation to show that HLA class I genotypes influence the effectiveness of multi-epitope vaccination strategies against SARS-CoV-2.

This paper develops deep-learning models to identify hypoxic tumor regions using MRI and histology, showing their effectiveness in predicting hypoxia and guiding TH-302 therapy response in sarcoma models.

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

The paper investigates the role of EphA3 in T cell acute lymphoblastic pre-leukemia stem cells, showing it enables the halt in differentiation of neighboring WT cells, allowing pre-leukemic cells to persist in the thymus.

This case study investigates the feasibility of direct EMG control of a powered ankle prosthesis combined with physical therapy training to improve postural control in a transtibial amputee.

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.