S. Kim

The paper shows polyubiquitinated PCNA promotes break-induced replication at telomeres and fragile sites by recruiting SLX4, leading to telomere damage and DNA synthesis.

This paper evaluates a novel antiglycolytic compound, BKIDC-1553, showing selective growth inhibition of prostate cancer cells and safety for clinical trials.

This study shows that Legionella pneumophila uses Sde proteins to modify Rtn4, forming ER aggregates that protect the Legionella-containing vacuole from host disruption.

The paper identifies a new RiPP subclass, pimtides, by analyzing the evolutionary spread of PIMT enzymes and their role in modifying precursor peptides.

The paper identifies torsinA's role in regulating NPC spatial organization during neuronal maturation without affecting NPC density.

This study shows that combining KRASG12C inhibitors with PAK4 inhibitor KPT9274 enhances antitumor activity and survival in preclinical models of KRASG12C mutant pancreatic and lung cancers.

This study identifies Sde proteins as temporally-regulated vacuole guards in Legionella pneumophila that prevent early vacuole disruption by blocking host endosomal trafficking.

The paper establishes a novel mouse model of persistent SARS-CoV-2 infection using Calu-3 xenografts and identifies spike protein mutations that enhance viral replication and host adaptation.

This study shows that repeated mRNA vaccination leads to BCR hypermutation, enabling antibodies to neutralize Omicron variants.

This study shows that partial in vivo reprogramming using OSKM factors induces intestinal regeneration via Ptgs1-driven prostaglandin synthesis, distinct from normal Ptgs2-dependent regeneration.

This study shows Lag3 supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis, which is critical for suppressing autoimmune inflammation.

This study shows that DNMT3A-destabilizing mutations in AML increase DNA methylation heterogeneity at bivalent chromatin domains, affecting leukemic stem cell-niche interactions and drug response.

This study examines spatial and compositional changes in papaya fruit characteristics during ripening across different fruit parts and stages.

This paper develops robust single-molecule tweezers using click chemistry and biotin-avidin binding to enable repetitive mechanical manipulation of membrane proteins.

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

The paper introduces a method to measure osmotic pressure in living tissues and finds a balance between intracellular and interstitial pressures in zebrafish embryos.

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

This study identifies SMYD3 as an epigenetic regulator that suppresses the intrinsic interferon response in HPV-negative HNSCC, offering a potential strategy to enhance immunotherapy response.

This study shows light-activated molecular machines can remotely stimulate intercellular calcium waves, controlling muscle contraction in vitro and animal behavior in vivo.

This study develops a pH-responsive peptide, PET1, that inhibits EGFR-mediated cell migration by disrupting transmembrane interactions, offering a new strategy for targeting RTKs with reduced side effects.

This paper shows that increasing local concentration of MPER-directed bnAbs via Fc{gamma}RI binding enhances HIV-1 neutralization, suggesting lipid-binding is not strictly required for potency.

This study evaluates the toxicity and efficacy of TNF-alpha inhibitors adalimumab and infliximab in preventing retinal cell apoptosis and optic nerve axon loss in rabbits after corneal injury.

The paper identifies a 3-smRC signature from circulating extracellular vesicles that detects early-stage liver cancer with high sensitivity and specificity.

This paper identifies a broadly neutralizing antibody from a snakebite survivor that protects against multiple snake venoms by targeting conserved neurotoxin epitopes.

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

This paper demonstrates label-free vibrational imaging of myelin in mouse brains through thick cranial bones using adaptive optics-enhanced coherent Raman scattering microscopy.

This study identifies genes essential for Legionella pneumophila survival in water using Tn-seq and CRISPRi, showing that electron transport chain genes and cell wall stability factors are critical for long-term viability.

This study shows that WDFY4 deficiency in NOD mice prevents autoimmune diabetes by blocking CD8 T cell priming, while preserving CD4 T cell activation and islet infiltration.

The paper identifies a nuclear jamming transition during vertebrate organogenesis, showing that nuclear packing influences tissue mechanics and architecture beyond cellular jamming.