S. Sarkar

This paper introduces a rapid method for counting bacterial colony-forming units using micro-colony observation, achieving results comparable to traditional dilution plating with reduced time and labor.

This paper models the biophysical processes determining the lifetime of actin-dependent protein nanoclusters and finds that actin aster fragmentation is only important for a small class of nanoclusters, while ligand lifetime near nanoclusters increases anomalously, matching RAS-RAF kinetics data.

This study investigates how porphyrins influence metal ion-mediated prebiotic reactions, showing enhanced catalytic activity and substrate versatility in metal-porphyrin complexes.

The paper analyzes genetic diversity of Trypanosoma cruzi in the Southwestern US, identifying two main lineages with significant divergence between them.

This study identifies XIAP as a novel substrate of USP7, showing that USP7 stabilizes XIAP to promote tumorigenesis by inhibiting apoptosis, and finds that combined inhibition of USP7 and XIAP enhances apoptosis.

This study identifies PAF1 complex members and p21 as key regulators of WEE1 inhibitor sensitivity, revealing their role in protecting cancer cells from replicative catastrophe through R-loop formation and DNA damage response.

This paper identifies RITA as a compound that selectively kills SETD2-deficient cancer cells by inducing p53-mediated apoptosis and replication stress.

This study shows that glycan remodeling and CD22 downregulation are essential for proper germinal center function, including plasma cell output and antibody affinity maturation.

This study uses simulations to investigate ATP's role as a hydrotrope, showing it can unfold hydrophobic macromolecules and disrupt aggregation, with charge reinforcement and self-aggregation contributing to its effectiveness.

This study evaluates an inhaled monoclonal antibody against SARS-CoV-2 in hamsters, showing reduced viral burden and lung pathology with low-dose inhalation.

The paper introduces SNAP, a deep learning pipeline for automated soybean nodule quantification with 99% accuracy, enabling efficient analysis of nodule traits and genetic-environmental interactions.

The paper studies how diffusion and advection affect information transmission in cell signaling using a one-dimensional model and finds that mutual information increases with advection when the Peclet number exceeds one.

The paper uses single-cell RNA-sequencing to analyze immune cells in ileal pouches and colons of UC patients, identifying specific cell types and their association with inflammation and treatment response.

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

The paper analyzes the genotypic and antigenic characteristics of an Indian SARS-CoV-2 isolate, identifying its strain and predicting B and T cell epitopes for vaccine design.

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

This study identifies promiscuous macrocyclases that enable the synthesis of diverse cyclic peptides without requiring thiazole/thiazoline termini.

This study shows that compositional heterogeneity in protocellular membranes enhances their stability under multiple prebiotic selection pressures, making them more suitable for supporting early life.

This study identifies EAAT1 as a critical target for T-ALL treatment by showing its role in glutamine conversion to nucleotides and aspartate essential for cell proliferation.

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.

This study investigates nonenzymatic oligomerization of cyclic nucleotides under prebiotically relevant conditions, showing that DH-RH cycles and amphiphiles promote RNA-like oligomer formation.

The paper uses multi-scale simulations to distinguish Ras dimerization-dependent from -independent Ras-Raf activation mechanisms.

The paper identifies bivalent chromatin states and broad H3K4me3 domains associated with pro-metastatic drivers in melanoma using ChIP-sequencing data from tumor samples and cell lines.

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

The paper shows that a soybean PBS1 decoy protein with a SMV NIa protease cleavage site triggers cell death and inhibits SMV spread, suggesting decoy engineering can be used in soybean and other crops.

This paper evaluates the structural and practical identifiability of a dual-input kinetic model for FDG PET in liver inflammation using Monte Carlo simulations and patient data.

This study shows that paternal exposure to adult density in Drosophila melanogaster affects offspring competitive ability and male fitness components, indicating paternal environment as a source of fitness variation.

This paper evaluates kinetic modeling approaches for dynamic FDG-PET of human liver inflammation, finding that an optimization-derived dual-blood input function model improves accuracy compared to single-blood and population-based models.

This study shows that trehalose induces autophagy in HIV-infected macrophages, reducing mycobacterial infections by inhibiting xenophagy flux and killing intracellular pathogens.

This paper develops a novel F. tularensis vaccine strain expressing ovalbumin to study CD8+ T cell responses, finding that these cells expand early, produce IFN-γ, and have distinct kinetics in different tissues.