S. Wang

This study identifies how Rabphilin 3A binds the N-peptide of SNAP-25 to enhance SNARE complex assembly, facilitating vesicle exocytosis.

The paper evaluates the confidence of individual amino acid residues in PDB macromolecular crystal structures using RSCC and compares it to AlphaFold2's pLDDT scores, finding RSCC better reflects experimental reliability.

This study identifies sex differences in beta cell stress responses, showing female beta cells are more resilient to ER stress in both human and mouse models.

The paper shows that Arabidopsis HSC70.1 binds its own mRNA to inhibit translation, forming a feedback loop that regulates chaperone availability and enables non-cell-autonomous homeostasis.

This paper develops a self-healing hydrogel that mimics brain parenchyma viscoelasticity to promote healing of brain lesions in mice.

This study analyzes Usutu virus genomes to identify lineage-specific codon usage patterns and host adaptation mechanisms.

The paper identifies ATM and KEAP1 as targetable vulnerabilities in solid tumors through a CRISPR metabolic screen revealing their synthetic lethality.

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

This study evaluates a multivalent mRNA vaccine encoding SARS-CoV-2 and SARS-CoV receptor-binding domains, showing it induces cross-neutralizing antibodies against multiple variants in mice.

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

This paper presents an integrated platform for high-throughput single-molecule localization microscopy (SMLM) that enables imaging of 10,000 cells per day.

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.

This study uses a LNA/DNA nanobiosensor to analyze Dll4 mRNA dynamics during osteogenic differentiation of hMSCs in 2D and 3D environments, showing Notch1-Dll4 signaling regulates osteogenesis and is active during differentiation.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

This study shows that a UB-612 booster vaccine significantly increases neutralizing antibodies against SARS-CoV-2 variants, including Omicron, with estimated 95% efficacy against the ancestral strain.

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

This study investigates how reducing chemical fertilizers and adding bio-organic fertilizer affects soil microbial communities and Baby Chinese cabbage yield in Gansu plateau, finding that T2 treatment yields the highest crop output.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.

The paper derives exact solutions for membrane fusion pores, identifying three families and showing dilation involves transitioning from a narrow to wide pore with an intermediate unstable state.

The paper assesses Trichodesmium diversity in the Red Sea using metagenomes and hetR gene phylotyping, finding that morphology and marker genes may not reliably reflect genetic diversity.

The paper identifies that memory precursor cells are continuously generated over time following acute infection, with increased numbers and effector gene expression observed later.

This paper introduces single-objective evanescent scattering microscopy for label-free single protein imaging and binding kinetics quantification with high spatiotemporal resolution.

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

The paper uses spatial single-cell analysis to show that CD73 and CD39 expression in glioblastoma correlates with poor clinical outcomes and immunosuppressive signaling.