S. Wang

This paper introduces a cryoFIB milling workflow for isolating objects of interest from large tissue samples, resulting in thin lamellae suitable for cryo-electron tomography.

The paper examines how tinamou egg coloration relates to mating signals and eco-geographical distribution, finding associations with song variables and differences in similar habitats.

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

This study identifies UBE2L3, TRIP12, and AREL1 as ubiquitin ligases that regulate pro-IL-1β turnover, limiting inflammation by reducing precursor availability.

The paper analyzes continental-scale root data and finds widespread root bimodality, with secondary root biomass peaks deeper than 60cm, linked to soil nitrogen content and vegetation type.

This study uses solid-state NMR to elucidate the molecular structure of drug-induced aberrant HBV capsid assemblies and reveals differences in capsid-RNA interactions and phosphorylation between in-cell and in vitro conditions.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

The paper develops a microfluidic array to study immune cell interactions in a tumor microenvironment, showing that anti-PD-L1 treatment improves T cell infiltration and reduces cancer cell apoptosis.

This study determines the cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP complexed with TPR-CHAT and target RNA, revealing its mechanism of RNA recognition and cleavage.

The paper shows that follicular dendritic cells (FDCs) in germinal centers (GCs) have distinct spatial organization that controls antigen retention, with central FDCs acting as long-term antigen reservoirs.

This paper demonstrates that an engineered nanobody-E3 ubiquitin ligase adapter fusion can effectively degrade tau in mouse neurons by leveraging nuclear proteasomal activity.

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

This paper introduces CP-seq, a method to test thousands of drug combinations on single cells using microwell-based droplet random pairing and single-cell RNA sequencing.

This paper identifies FAK-SFK signaling as a mechanism linking ECM rigidity sensing and ERBB2 activation to YAP-driven invasive growth and metastasis in HER2+ breast cancer.

This study investigates how fluid shear stress regulates osteogenic differentiation of hMSCs through Notch signaling using an LNA/DNA nanobiosensor and pharmacological inhibition.

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

This study uses cryo-EM to reveal structural details of TRiC/CCT-mediated folding of tubulin and actin with plp2, showing how plp2 coordinates substrate translocation and folding.

The paper identifies an unexpected histone chaperone function for the MIER1 histone deacetylase complex, showing its ability to bind histone dimers and octamers and associate with nucleosomes.

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

This study identifies how melanoma cells use pericyte:endothelial cell signaling during brain invasion, showing that Sox9hi mesenchymal cells use Snail1-dependent mechanisms while Sox10hi cells form clusters.

The paper introduces a method to detect and analyze i6A-modified RNA with single-base resolution using iodine-mediated oxidation and reverse transcription.

The paper shows that historical parental population expansion before secondary contact can lead to heterosis in hybrids by reducing the negative effects of Bateson-Dobzhansky-Muller incompatibilities.

This paper introduces wide-field plasmonic thermal microscopy (W-PTM) for rapid local temperature regulation and demonstrates its use in modulating TRPV1 ion channels in living cells.

The paper computationally designs and experimentally validates potent inhibitors of the SARS-CoV-2 Nsp3 Macrodomain, identifying 160 ligands and 152 crystal structures with submicromolar affinity.

This study shows that long-term exposure to cyhalofop-butyl (CyB) at environmental concentrations harms zebrafish reproduction and causes developmental abnormalities in offspring.

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

The paper develops an interpretable XGBoost-SHAP model to predict nanoparticle delivery efficacy by integrating physicochemical properties and tumor genomic profiles, showing strong predictive performance and highlighting key genomic interactions.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.