S. Yang

The paper shows CYFIP2-containing WAVE complexes restrain RAC1 activation, affecting cell migration, and mutations in CYFIP2 can enhance its activity.

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

This study shows that targeting SCARB1 with HDL NPs in cholesterol-dependent lymphoma cells reduces GPX4, leading to ferroptosis and cell death.

The paper shows that the mitotic kinase Polo also directs cellular morphogenesis after cell cycle exit, with its activity regulated by different upstream kinases during mitosis and post-mitosis.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.

This study shows that transient hyperglycemia causes long-term vascular endothelial dysfunction and delayed wound healing through DNMT1-mediated Ang-1/NF-κB pathway activation.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This paper adapts and evaluates a phasor-based single-molecule localization microscopy algorithm for engineered PSFs, achieving comparable precision to existing methods with improved speed.

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

This study identifies altered B cell subset homeostasis in IgAV patients, with increased plasmablasts and decreased specific memory B cells, correlating with IgA levels.

This paper uses a hindcast simulation to analyze biogeochemical variability in the California Current System from 1995-2010, showing how nutrient and light limitations drive productivity and how climate events like El Nino affect ecosystem states.

The paper reveals how the BBSome facilitates GPCR transport across the transition zone by extracting amphipathic helices from the inner leaflet of the membrane.

This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.

This study finds that patients with heart failure have a higher risk of developing cancer compared to the general population, with increased risk observed across multiple cancer types.

This study shows that Cep57 and Cep57l1 recruit the Cep63-Cep152 complex to mother centrioles, enabling centriole duplication.

This study combines metagenomic sequencing and host response profiling to improve sepsis diagnosis by detecting pathogens and guiding clinical decisions.

This study integrates radiomic and genomic data from HNSCC patients to find associations between imaging features and genomic biomarkers, achieving moderate predictive accuracy for HPV and TP53 mutation status.

This paper introduces a rapid antimicrobial susceptibility test using laser speckle dynamics to detect bacterial growth in 2-4.5 hours.

This study shows YAP1 is increased in high-grade prostate adenocarcinoma but reduced in neuroendocrine prostate cancer, with YAP1 loss activating Wnt/beta-Catenin signaling linked to NEPC development.

The paper develops a robust CNN for diabetic retinopathy screening by addressing dataset size, data curation, and performance metrics using cloud-based methods.

The paper identifies phosphorylation of H3.3S31 in response to pathogen sensing in macrophages and shows its role in recruiting SETD2 to enhance transcription of inflammatory genes.

The paper tests metagenomic sequencing with ONT MinION for strain-level identification of bacterial tomato pathogens, achieving success with Pto but showing challenges with field samples.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

This study uses RNA-seq to analyze tlr2 mutant zebrafish and finds TLR2 plays a role in transcriptional control, metabolism, and defense against Mycobacterium marinum.

The paper uses X-ray diffraction and electron microscopy to show that rat soleus muscle has a simple thick filament lattice, while extensor digitorum longus has a super lattice, correlating with slow and fast fiber types respectively.

MATE-Seq identifies antigen-specific T-cell receptors by isolating and sequencing T-cells bound to peptide-MHC tetramers with high sensitivity.

This study identifies molecular and cellular differences between murine syngeneic tumor models and human tumors, highlighting limitations in using syngeneic models for immunotherapy research.

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.

This paper identifies carbon starvation stress as a trigger for the PprB regulon in Pseudomonas aeruginosa, revealing its role in enhancing biofilm adhesion through BapA and CupE.